Use of insulin-like growth factor binding protein 3...

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector

Reexamination Certificate

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Reexamination Certificate

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10366881

ABSTRACT:
A method of inhibiting proliferation of cells associated with a tumor in a subject which comprises administering to the subject a tumor cell proliferation amount of IGF-BP3, thereby inhibiting proliferation of the cells. An improved surgical method which comprises surgically resecting a tumor from a subject and administering to the subject an amount of a protein effective to inhibit metastasis of any tumor cells released in the subject's blood circulation during the surgical resection of the tumor.

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Lee, S. W.; Gleason, N. R.; Ssenymanturo, K.; Woodring, J.; Bessler, M.; Whelan, R. L. Colon cancer tumor proliferative index is higher and tumor cell death rate is lower in mice undergoing laparotomy vs. insufflation.Surg. Endosc. 1998, 12, 514 (Exhibit 13).
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