IL6RIL6 chimera for the treatment of neurodegenerative diseases

Details IL6RIL6 chimera for the treatment of neurodegenerative diseases IL6RIL6 chimera for the treatment of neurodegenerative diseases

2007-04-10

2007-04-10

O'hara, Eileen (Department: 1647)

Drug, bio-affecting and body treating compositions

Lymphokine

Interleukin

C424S085100, C514S012200, C530S351000

Reexamination Certificate

active

09980823

ABSTRACT:
The invention relates to the use of IL6RIL6 chimera in the treatment and prevention of neurological diseases and disorders.

REFERENCES:
patent: 1999/0048413 (1999-02-01), None
patent: WO 99/02552 (1999-01-01), None
Barinaga, M. Science, vol. 264, pp. 772-773, May 1994.
XP-002156155—Haggiag et al., “Induction of myelin gene expression in cell cultures by an IL6 receptor IL6 chimera”,Neuroscience Letters, 54:S19 (1999).
XP-002156153—Haggiag et al., “Induction of myelin gene expression in Schwann cell cultures by an interleukin-6 receptor-interleukin-6 chimera”,FEBS Letters, 457:200-204 (1999).
XP-000971298—Ringheim et al., “Enhancement of beta-amyloid precursor protein transcription and expression by the soluble interleukin-6 receptor/interleukin-6 complex”,Molecular Brain Research, 55:35-44 (1998).

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