Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Reexamination Certificate
2007-03-06
2007-03-06
Woitach, Joseph (Department: 1632)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
C536S023100, C536S024100
Reexamination Certificate
active
10096549
ABSTRACT:
The invention provides methods for using local heat to control gene expression. The heat shock protein (hsp) gene promoter is recombined with a selected therapeutic gene and expressed in selected cells. Local controlled heating is used to activate the hsp promoter, for example by using focused ultrasound controlled by MRI.
REFERENCES:
patent: 5490840 (1996-02-01), Uzgiris et al.
patent: 5521084 (1996-05-01), Kowalski et al.
patent: 0 118 393 (1984-09-01), None
patent: 0 263 908 (1988-04-01), None
patent: 0 299 127 (1989-01-01), None
patent: 0 336 523 (1989-10-01), None
patent: WO 87/00861 (1987-02-01), None
patent: WO 87/04727 (1987-08-01), None
patent: WO 87/05935 (1987-10-01), None
patent: WO 90/01543 (1990-02-01), None
patent: WO 90/11092 (1990-10-01), None
patent: WO 95/00178 (1995-01-01), None
patent: WO 95/03418 (1995-02-01), None
Angles, J. M. et al., “Effects of pulsed ultrasound and temperature on the development of rat embryos in culture”Teratology, vol. 42; pp. 285-293 (1990).
Burdon, R. H., “Heat shock proteins in relation to medicine”,Molec. Aspects Med., vol. 14; pp. 83-165 (1993).
Cline, H. E. et al., “Focused US system for MRI imaging-guided tumor ablation”Radiology, vol. 194; pp. 731-737 (1995).
Voellmy, R., “Transduction of the stress signal and mechanisms of transcriptional regulation of heat shock/stress protein gene expression in higher eukaryotes” Crit. Rev. Eukar. Gene Expr., vol. 4, No. 4; pp. 357-401 (1994).
de Zwvart, J. A. et al., “Ultra fast MRI thermometry” Abstract for Scientific Presentation at the Society of Magnetic Resonance 4th Scientific Meeting, New York, NY, Apr. 27-May 3, 1996.
de Zwart, J. A. et al., “Fast magnetic-resonance temperature imaging” J. Magnetic Resonance, Ser. B-112, Art. No. 0115, pp. 86-90 (1996).
Amin, H. et al.: “Organization of theDrosophila melanogasterhsp70 heat shock regulation unit”Mol. Cell. Biol.; Mar. 1987; pp. 1055-1062.
Anderson, W. F.: “Human gene therapy”Nature; vol. 392; Apr. 30, 1998; pp. 25-30.
Crystal, R. G.: “Transfer of genes to humans: Early lessons and obstacles to success”Science; vol. 270; Oct. 20, 1995; pp. 404-410.
Dreano, M. et al.: “High-level, heat-regulated synthesis of proteins in eukaryotic cells”Gene; vol. 49; 1986; pp. 1-8.
Dreano, M. et al.: Production of secretable proteins using the passage in vivo as tomours of cells carrying heat-inducible expression constructsBiotechnology; vol. 6, Aug. 1988; pp. 953-958.
Fan, X. and K. Hynynen: “Control of the necrossed tissue volume during noninvasive ultrasound surgery using a 16-element phased array”Med. Phys.; vol. 22, No. 3; Mar. 1995; pp. 297-306.
Hynynen et al.: “MRI-guided noninvasive ultrasound surgery”Med. Phys.; vol. 20, No. 1; Jan./Feb. 1993; pp. 107-115.
Rancourt, E. et al.: “Flounder antifreeze protein synthesis under heat shock control inDrosophila melanogaster”Mol. Cell. Biol.; Jun. 1987; pp. 2188-2195.
Stedman's Medical Dictionary, Williams & Wilkins, 1995.
Verma et al.: “Gene therapy—promises, problems and prospects”Nature; vol. 389; Sep. 18, 1997; pp. 239-242.
Craig, E.A. and C.A. Gross: “Is hsp70 the cellular thermometer?”Trends Bioch. Sci. vol. 16; pp. 135 (1991).
Dreano, M. et al. (1998) “Antibody formation against heat-induced gene products expressed in animals”Bio/Technologyvol. 6, No. 11; pp. 1340-1343.
Hightower, L.E.: “Heat shock, stress proteins, chaperones and proteotoxicity”Cell, vol. 66; pp. 191-197 (1991).
Holbrook, N.J. and Udelsman: “Heat shock protein gene expression in response to physiological stress and aging,” in The Biology of Heat Shock Proteins and Molecular Chaperones (Morimoto et al. eds., Plainview, NY: Cold Spring Harbor Laboratory Press, pp. 577-593) (1994).
Hunt, C. and R.I. Morimoto: “Conserved features of eukaryotic hsp70 genes revealed by comparison with the nucleotide sequence of human hsp70”Proc. Natl. Acad. Sci. USA; vol. 82., pp. 6455-6459 (1985).
Kay, R. J. et al.: “Expression of intron-containingC. elegansheat shock genes in mouse cells demonstrates divergence of 3′splice site recognition between nematodes and vertebrates, and an inhibitory effect of heat shock on the mammalian splicing apparatus”Nucl. Acids Res.; Vo. 15, No. 9; pp. 3723-3741 (1987).
Lis, J. and C. Wu: “Protein traffic on the heat shock promoter: Parking, stalling, and trucking along”Cell; vol. 74; pp. 1-4 (1993).
Macario, (1995), “Heat-shock proteins and molecular chaperones: Implications for pathogenesis, diagnostics, and therapeutics,”Int. J. Chem. Lab Res. vol. 25; pp. 59-70 (1995).
Miller, M.W. and M.C. Ziskin: “Biological consequences of hyperthermia”Ultrasound Med. Biol.vol. 15, No. 8; pp. 707-722 (1989).
Miller, A.D.: “Human gene therapy comes of age”Nature; vol. 357; pp. 455-460 (1992).
Morimoto et al., eds., Stress Proteins in Biology and Medicine (1990) Cold Spring Harbor Press (1990) esp. Chapters 5 and 6 (pp. 101-130) and pp. 248-252; pp. 255-268.
Mulligan, R.C. “The basic science of gene therapy”Sciencevol. 260; pp. 926-932 (1993).
Samulski, T.V. et al.: “Non-invasive thermometry using magnetic resonance diffusion imaging: potential for application in hyperthermic oncology”int. J. Hyperthermia, vol. 8, No. 6, pp. 819-829 (1992).
Wu, B., et al. “Structure and expression of the human gene encoding major heat shock protein HSP70”Mol. Cell. Biol.vol. 5, No. 2: pp. 330-341 (1985).
Yost, H.J. and S. Lindquist: “RNA splicing is interrupted by heat shock and is rescued by heat shock protein synthesis”Cellvol. 45; pp. 185-193 (1986).
Klarquist & Sparkman, LLP
The United States of America as represented by the Department of
Woitach Joseph
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