Piperidine derivatives and their use as modulators of...

Details Piperidine derivatives and their use as modulators of... Piperidine derivatives and their use as modulators of...

2007-07-03

2007-07-03

Saeed, Kamal A. (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C544S129000

Reexamination Certificate

active

10489811

ABSTRACT:
The invention provides a compound of formula (I): T is C(O) or S(O)2; W is CH2, (CH2)2, CH(CH3), CH(CH3)O or cyclopropyl; X is O, CH2, C(O), S, S(O), S(O)2or NR3; m is 0 or 1; R1is optionally substituted aryl or optionally substituted heterocyclyl; R2is alkyl (optionally substituted by OH), cycloalkyl, optionally substituted aryl or optionally substituted heterocyclyl; that are modulators of chemokine (especially CCR3) activity and are especially useful for treating asthma and/or rhinitis.

REFERENCES:
patent: 4695575 (1987-09-01), Janssens et al.
patent: 5883096 (1999-03-01), Lowe et al.
patent: 5889006 (1999-03-01), Lowe et al.
patent: 5952349 (1999-09-01), Asberom et al.
patent: 5977138 (1999-11-01), Wang et al.
patent: 6066636 (2000-05-01), Kozlowski et al.
patent: 6387930 (2002-05-01), Baroudy et al.
patent: 6440440 (2002-08-01), Meerpoel et al.
patent: 6759411 (2004-07-01), Ko et al.
patent: 6903115 (2005-06-01), Rigby et al.
patent: 0 099 139 (1984-01-01), None
patent: 0 121 972 (1984-10-01), None
patent: 0 145 037 (1985-06-01), None
patent: 0 151 824 (1985-08-01), None
patent: 0 151 826 (1985-08-01), None
patent: 1 076 055 (2001-02-01), None
patent: 1250719 (1971-10-01), None
patent: WO 93/10091 (1993-05-01), None
patent: WO 95/08535 (1995-03-01), None
patent: WO 96/26196 (1996-08-01), None
patent: WO 96/34857 (1996-11-01), None
patent: WO 96/41631 (1996-12-01), None
patent: WO 97/24324 (1997-07-01), None
patent: WO 98/01425 (1998-01-01), None
patent: WO 98/05291 (1998-02-01), None
patent: WO 98/05292 (1998-02-01), None
patent: WO 98/06697 (1998-02-01), None
patent: WO 98/11128 (1998-03-01), None
patent: WO 99/04794 (1999-02-01), None
patent: WO-99/38514 (1999-05-01), None
patent: WO 99/37304 (1999-07-01), None
patent: WO 99/38514 (1999-08-01), None
patent: WO 99/51578 (1999-10-01), None
patent: WO 00/00488 (2000-01-01), None
patent: WO 00/12478 (2000-03-01), None
patent: WO 00/32590 (2000-06-01), None
patent: WO 00/35877 (2000-06-01), None
patent: WO 00/66559 (2000-11-01), None
patent: WO 01/02381 (2001-01-01), None
patent: WO 01/07436 (2001-02-01), None
patent: WO 01/29066 (2001-04-01), None
patent: WO 01/77101 (2001-10-01), None
patent: WO 01/92227 (2001-12-01), None
patent: WO 02/18335 (2002-03-01), None
patent: WO 02/20484 (2002-03-01), None
patent: WO 02/079190 (2002-10-01), None
patent: WO 02/081449 (2002-10-01), None
patent: WO 03/004487 (2003-01-01), None
patent: WO 03/018576 (2003-03-01), None
patent: WO 03/078395 (2003-09-01), None
patent: WO 03/078421 (2003-09-01), None
patent: WO 2004/029041 (2004-04-01), None
patent: WO 2004/085423 (2004-10-01), None
patent: WO 2004/087659 (2004-10-01), None
patent: WO 2004/099144 (2004-11-01), None
Allain et al., (2005) STN International, HCAPLUS Database, Columbus, OH, Accession No. 1992:187881, Reg. No. 46817-91-8, citing “Antidepressants and cognition: comparative effects of moclobemide, viloxazine and maprotiline”,Psychopharmacology106 (Suppl.).
Cohen et al.,Am. J. Clin. Pathol. 105:589 (1996).
Hermans et al., “4-Substituted Piperidines. II. Reaction of 1-Benzyl-4-cyano-4-t-aminopiperidines with Organometallic Compounds”,J. Med. Chem.8(6):851-855 (1965) at p. 852 (“compound 12” in Table I).
Patani and LaVoie, “Bioisosterism: A Rational Approach in Drug Design”,Chem. Rev.96:3147-3176 (1996).
STN International, File CAPLUS, CAPLUS accession No. 1988:630911, Document No. 109:230911, Lehmann, Jochen et al: “Lactones. XVIII. Synthesis of lactone-bridged 1,1-diarylpropanamines”; &Arch. Pharm.(Weinheim, Ger.) (1988), 321(7), 443-445.

Affiliated with

Also associated with

Rating

Piperidine derivatives and their use as modulators of... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Piperidine derivatives and their use as modulators of..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Piperidine derivatives and their use as modulators of... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3746535