Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Reexamination Certificate
2007-05-29
2007-05-29
Weber, Jon (Department: 1654)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
C435S069600, C530S362000, C530S363000, C530S414000, C530S416000, C530S417000, C530S420000, C514S004300, C514S012200, C514S021800
Reexamination Certificate
active
10873504
ABSTRACT:
A process is provided for the preparation of albumin which has extremely low levels of or is essentially free of colorants, metal ions, human proteins, host proteins, fragments of albumin, polymers or aggregates of albumin and viruses, and which is essentially non-glycated, relatively high in free thiol and with an intact C-terminus. The process comprises passing albumin (preferably expressed and secreted by transformed yeast) through positive mode cation exchange and then positive mode anion exchange chromatography. Other steps may also be employed, ultrafiltration, gel permeation chromatography, affinity chromatography binding the albumin by using blue dyes) and affinity chromatography binding contaminants by using an aminophenylboronic acid resin. Elution of albumin, with a compound having affinity for albumin, from a material having no specific affinity for albumin is also disclosed, as is removal of ammonium ions with a counter-ion.
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Berezenko Stephen
Burton Stephen James
Goodey Andrew Robert
Johnson Richard Alan
Quirk Alan Victor
Mohamed Abdel A.
Novozymes Delta, Limited
Synnestvedt & Lechner LLP
Weber Jon
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