Indolyl derivatives

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C548S462000

Reexamination Certificate

active

11074474

ABSTRACT:
This invention relates to compounds of the formula I:wherein one of R6, R7and R8isand R1to R15and n are as defined in the description, and all enantiomers and pharmaceutically acceptable salts and/or esters thereof. The invention further relates to pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are modulated by PPAR δ and/or PPARα agonists.

REFERENCES:
patent: WO 03/074051 (2003-09-01), None
patent: WO2004063190 (2004-07-01), None
Oliver, et. al., Proc Nat Acad Sci USA (2001) 98:5306-11.
Guerre-Millo, et. al., J. Biol Chem (2000) 275:16638-16642.
Jones, et. al., J. Chem. Soc (1953), 2548.
E.J. Corey, et. al., J. Am. Chem. Soc (1987) 109, 5551-5553.
P.V. Ramachandran, et. al., Tetrahedron: Asymmetry (1994) 5, 1061-1074.
Nichols, et. al., (1998) Anal. Biochem. 257, 112-119.

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