Method of compensating for offset distortion in rows of electrop

Details Method of compensating for offset distortion in rows of electrop Method of compensating for offset distortion in rows of electrop

1986-04-21

1988-01-19

Smith, Jerry

Boots, shoes, and leggings

435 6, 935 77, C12Q 168, G01N 3358

Patent

active

047207868

ABSTRACT:
The base sequence of nucleic acids is determined by subjecting digital signals to signal processing, where the digital signals correspond to an autoradiograph of plural resolved rows which are formed by resolving a mixture of base-specific DNA fragments or base-specific RNA fragments labeled with a radioactive element in one-dimensional direction on a support medium.
The method involves detecting at least two bands in the lower part of each resolved row and numbering the bands consecutively from the lower end, obtaining correlation between the band's number and a resolved distance thereof for each resolved row, and then determining the difference in the resolved distance between the resolved rows from the resulting correlation and making correction for the resolved position on each row by taking the difference as a locational deviation of the rows from each other.

REFERENCES:
Sanger, F. et al. "DNA Sequencing with Chain-Terminating Inhibitors," Proc. Natl. Acad. Sci., vol. 74, No. 12, Dec. 1977, 5463-5467.

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