Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing
Reexamination Certificate
2007-04-03
2007-04-03
Campell, Bruce R. (Department: 1648)
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
C530S326000
Reexamination Certificate
active
10397507
ABSTRACT:
A method for efficiently searching novel physiologically active substances under a certain predictability. This searching method comprises, among receptors of cells producing an antagonist to a substance in vivo or receptors of cells producing an antagonist to the cells per se, finding a receptor having amino acid sequences of two or more sizes by comparing the cDNA sequences of the receptor, and then examining which region in the longer receptor is missed in the shorter receptor by comparing the above cDNA sequences. By using this method, remedies for diabetes comprising a peptide having the amino acid sequence represented by SEQ ID NO:1 or 5, insulin production regulators comprising a peptide having the amino acid sequence represented by SEQ ID NO:2, and gastric secretion inhibitors comprising a peptide having the amino acid sequence represented by SEQ ID NO:3 or 4 are provided.
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Song I et al. The human gastrin/cholecystokinin type B receptor gene: Alternative splice donor site in exon 4 generates two variant MRNAs. Proc.natl.Acad.Sci.USA., 90: 9085-9089, 1993.
Naranda T et al. A peptide derived from an extracellular domain selectively inhibits receptor internalization: target sequences on insulin and insulin-like growth factor I receptors. Proc.Natl.Acad.Sci.USA., 94: 11692-11697, 1997.
Brooks & Kushman PC
Campell Bruce R.
Li Bao Qun
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