Method of screening for agents that regulate the shedding of...

Details Method of screening for agents that regulate the shedding of... Method of screening for agents that regulate the shedding of...

2007-07-10

2007-07-10

Monshipouri, Maryam (Department: 1656)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C435S015000

Reexamination Certificate

active

10471122

ABSTRACT:
The present invention provides a method of screening for agents which may regulate or inhibit the activities of TACE and TGF-α. These agents may act by enhancing or inhibiting the activity of DGK-δ. An activity of DGK-δ is the enzymatic conversion of DAG to PA. The method includes contacting a cell or organism with a test agent determining the activity of DGK-δ within the cell. An agent with reduces or increases the activity of DGK may be used to regulate or inhibit the activity of TACE and TGF-α. Such agents can be used to treat diseases such as cancer where cell growth and division and inflamation are important factors.

REFERENCES:
Sakane et al., J.B.C., 271(14), 8394-8401, 1996.
Zhao, Jinsong, “Pulmonary Hypoplasia in Mice Lacking Tumor Necrosis Factor-α Converting Enzyme Indicates an Indispensable Role for Cell Surface Protein Shedding during Embryonic Lung Branching Morphogensis.” Development Biology, 232, 204-218 (2001).

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