Method for synthesizing derivatives of...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C548S452000

Reexamination Certificate

active

10547132

ABSTRACT:
Process for the synthesis of compounds of formula (I):wherein R1represents hydrogen, alkyl or benzyl and R2represents a protecting group for the amine function.Application in the synthesis of perindopril and pharmaceutically acceptable salts thereof.

REFERENCES:
patent: 4933361 (1990-06-01), Holger et al.
patent: 2006/0149082 (2006-07-01), Dubuffet et al.
patent: WO 0158868 (2001-08-01), None
patent: WO 03016336 (2003-02-01), None
M Vincent, et al. “Stereoselective Synthesis of a New Perhydroindole Derivative of Chiral Iminodiacid, a Potent Inhibitor of Agiotensin Converting Enzyme”, TETRAHEDRON, vol. 23, No. 16, p. 1677-1680, 1982.
International Search Report: PCT FR2004 000445, Aug. 6, 2004.
International Preliminary Examination Report: PCT 2004 000445, Aug. 31, 2004.
International Preliminary Report on Patentability: PCT/FR2004/000445—Sep. 29, 2005.

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