Method for identification of modulators of pre-adipocyte...

Details Method for identification of modulators of pre-adipocyte... Method for identification of modulators of pre-adipocyte...

2007-09-11

2007-09-11

Ketter, James (Department: 1636)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C530S350000

Reexamination Certificate

active

10491643

ABSTRACT:
The invention relates to a method for identification of a compound which modulates pre-adipocyte differentiation comprising testing whether the compound modulates the activity and/or amount of O/E-1 and/or O/E-2 and/or O/E-3. The invention also relates to use of a compound able to modulate the activity or amount of O/E-1 and/or O/E-2 and/or O/E-3 in preparation of a medicament for the treatment or prevention of atherosclerosis, dyslipidemia, IRS, and type 2 diabetes.

REFERENCES:
patent: 1158044 (2000-02-01), None
patent: WO-00/44882 (2000-08-01), None
patent: WO-00/46348 (2000-08-01), None
patent: WO-01/64238 (2001-09-01), None
Dowell et al., “Olf-1/Early B Cell Factor is a Regulator ofglut4Gene Expression in 3T3-L1 Adipocytes,” The Journal of Biological Chemistry 277(3):1712-1718 (2002).
Milatovich et al., “Gene for a Tissue-specific Transcriptional Activator (EBF or OLF-1), Expressed iin Early B Lymphocytes, Adipocytes, and Olfactor Neurons, is Located on Human Chromosome 5, Band q34, and Proximal Mouse Chromosome 11,” Mammalian Genome 5:211-215 (1994).
Hagman et al., “EBF Contains a Novel Zinc Coordination Mofit and Multiple Dimerization and Transcriptional Activation Domains,” The Embo Journal 14(12):2907-2916 (1995).

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