Substituted tetrahydroisoquinoline compounds, methods of...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C546S139000

Reexamination Certificate

active

10389651

ABSTRACT:
The present invention relates to novel substituted tetrahydroisoquinoline compounds, pharmaceutical compositions containing the compounds, methods of making the compounds, and methods of using the compounds to destroy a target cell, such as a cancer cell, and to treat or prevent a cancerous condition.

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Parmee et al, Bioorganic & Medicinal Chemistry, vol. 10, pp. 2283-2286, Jun. 2000.
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Bermejo et al., “Syntheses and Antitumor Targeting G1 Phase of the Cell Cycle of Benzoyldihydroisoquinolines and Related 1-Substituted Isoquinolines,”J. Med. Chem. 45:5058-5068 (2002).

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