Human-type anti-blood coagulation factor VIII antibody

Details Human-type anti-blood coagulation factor VIII antibody Human-type anti-blood coagulation factor VIII antibody

2007-05-08

2007-05-08

Ewoldt, G. R. (Department: 1644)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C530S387300, C530S388250, C424S134100, C424S135100, C424S145100

Reexamination Certificate

active

10344514

ABSTRACT:
The present invention provides a human antibody against blood coagulation factor VIII (hereinafter also referred to as “FVIII”) and an antibody fragment that binds to human FVIII and specifically inhibits the coagulation activity of human FVIII. ScFv display phage libraries, prepared by using scFv DNAs constructed by random combinations of immunoglobulin VH chain genes and VL chain genes from lymphocytes from hemophilia A patients, is reacted with FVIII immobilized to a solid phase via anti-FVIII monoclonal antibody, and scFv clones capable of binding to FVIII are cloned to reveal VH and VL chains of FVIII-specific antibody.

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