Intermediate compounds for the preparation of mirtazapine...

Details Intermediate compounds for the preparation of mirtazapine... Intermediate compounds for the preparation of mirtazapine...

2007-09-04

2007-09-04

Bernhardt, Emily (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C564S155000

Reexamination Certificate

active

10488909

ABSTRACT:
The present invention is directed to intermediate compounds of mirtazapine and methods for obtaining same. A method is described for obtaining (±)-3-phenyl-1-methylpiperazine, an important intermediate for obtaining mirtazapine, which is based on imposing a cyclization reaction, in the presence of a reducing agent, on new compounds of general formula (1)in which Z is a leaving group capable of undergoing a nucleophilic displacement. A method is also described for obtaining the new compounds of formula (1).

REFERENCES:
patent: 3102068 (1963-08-01), Tolbert
patent: 5378729 (1995-01-01), Kohn et al.
patent: 5681962 (1997-10-01), Callander
patent: 2585702 (1985-07-01), None
patent: WO 00/63185 (2000-10-01), None
Van Der Burg, W.J.,J. Med. Chem, vol. 132, No. 1 (1970) pp. 35-39.

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