Process for producing trans-4-hydroxy-L-proline

Details Process for producing trans-4-hydroxy-L-proline Process for producing trans-4-hydroxy-L-proline

2007-07-03

2007-07-03

Nashed, Nashaat T. (Department: 1656)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing alpha or beta amino acid or substituted amino acid...

C435S189000, C435S252330, C435S254100, C536S023200, C536S023100

Reexamination Certificate

active

10610561

ABSTRACT:
The present invention is directed to a process for producing trans-4-hydroxy-L-proline, which is useful as a raw material for medicines or as an additive to foods. In the process, L-proline is converted into trans-4-hydroxy-L-proline in the presence of an enzyme source which is derived from a microorganism belonging to the genusDactylosporangium, AmycolatopsisorStreptomycesand which catalyzes the hydroxylation of L-proline into trans-4-hydroxy-L-proline, a divalent iron ion and 2-ketoglutaric acid, in an aqueous medium, and the produced trans-4-hydroxy-L-proline is collected from the aqueous medium. In addition, the present invention is directed to a process for producing trans-4-hydroxy-L-proline, wherein the L-proline biosynthesis activity of the host cell of the transformant is reinforced.

REFERENCES:
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patent: 0555475 (1993-08-01), None
Onishi et al,Biochemical and Biophysical Research Communications, 120, 45-51, (1984).
Baldwin et al,Tetrahedron Letters, 34, 7,489-7.492 (1993).
Lawrence et al. “Purification and initial characterization of proline 4-hydroxylase fromStreptomyces griseovirdusP8648: a 2-oxyacid ferrous-dependent dioxygenase involved in etamycin biosynthesis” Biochem. J. 313, 185-191.
Webster's Third New International Dictionary, Gove, ed. G. & C. Merriam Company, Springfield, Mass.
Bergey's Manual of Systematic Bacteriology, vol. 4Williams&Wilkins(1989), pp. 2440-2442.

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