Peptide mimics of conserved gonococcal epitopes and methods...

Details Peptide mimics of conserved gonococcal epitopes and methods... Peptide mimics of conserved gonococcal epitopes and methods...

2007-03-13

2007-03-13

Devi, S. (Department: 1645)

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

C424S234100, C424S190100, C424S193100, C514S002600, C530S300000, C530S825000, C530S350000

Reexamination Certificate

active

09699224

ABSTRACT:
The present invention relates to peptide mimics of a conserved gonococcal epitope ofNeisseria gonorrhoeae, which epitope is not found on human blood group antigens. This invention also relates to methods and compositions using such peptide mimics for the prophylaxis of gonorrheal infections.

REFERENCES:
patent: 5051408 (1991-09-01), Cooper
patent: 5476784 (1995-12-01), Rice et al.
patent: 5780029 (1998-07-01), Ferrone et al.
patent: 5888509 (1999-03-01), Rice et al.
patent: 5939067 (1999-08-01), Rice et al.
patent: 6048527 (2000-04-01), Granoff et al.
patent: 6074641 (2000-06-01), Rice et al.
patent: 6099839 (2000-08-01), Rice et al.
patent: 6479639 (2002-11-01), Metchetner et al.
patent: 2003/0026764 (2003-02-01), Griffiths
patent: WO 85/04654 (1985-10-01), None
patent: WO 94/22479 (1994-10-01), None
patent: WO 97/46582 (1997-12-01), None
patent: WO 98/46645 (1998-10-01), None
patent: WO 99/11660 (1999-03-01), None
patent: WO 99/40189 (1999-08-01), None
Tam J.P. In: Peptide Antigens: A Practical Approach. (Ed) C.B. Wisdom. IRL Press, Oxford University Press, New York, 1993, pp. 83-90.
Ngampasutadol et al. In: Abstracts of the 11th International Pathogenic Neisseria Conference, Nice, France, 1998, p. 159.
Clements. Infect. Immunol. 58: 1159-1166, 1990.
Huang et al. Mol. Immunol. 31: 1191-1199, 1994.
Tam. In: Peptide Antigens. A Practical Approach. (Ed) Wisdom G.B. IRL Press, Oxford University Press, New York, pp. 83-90, 1994.
Ahearn, J. M., M. B. Fischer, D. Croix, S. Goerg, M. Ma, J. Xia, X. Zhou, R. G. Howard, T. L. Rothstein, and M. C. Carroll. 1996. Disruption of the Cr2 locus results in a reduction in B-1a cells and in an impaired B cell response to T-dependent antigen. Immunity 4:251.
Apicella, M.A., M.A.J. Westerink, S.A. Morse, H. Schneider, P.A. Rice and J.M. Griffiss. 1986. Bactericidal antibody response of normal human serum to the lipooligosaccharadeNeisseria gonorrhoeae. J. Infect. Dis.153:520-526.
Amon, R., M. Shapira and C.O. Jacob. 1983. Synthetic Vaccines. J. Immunol. Methods 61: 261-273.
Banerjee A., R. Wang, S. N. Uljon, P. A. Rice, and E. C. Gotschlich. 1998 Identification of the gene (lgtG) encoding the lipooligosaccharide β chain synthesizing glucosyl transferase fromNeisseria gonorrhoeae. Proc. Natl. Acad. Sci. USA 95:10872.
Böttger, E. C., and D. Bitter-Suermann. 1987. Complement and the regulation of humoral immune responses. Immunol. Today 8:261.
Britigan, B.E., M.S. Cohen and P.F. Sparling. 1985. Gonococcal infection: a model of molecular pathogenesis.N. Eng. J. Med.312:1683-1694.
Brodin, N.T., J. Dahmén, B. Nilsson, L. Messeter, S. Mårtenson, J. Heldrup, H.O. Sjögren and A. Lundblad. 1988. Monoclonal antibodies produced by immunization with neoglycoproteins containing Galα1→4β1→4G1cβ-O and Galα1→4β1→4G1cNAcβ-O residues: useful immunochemical and cytochemical reagents for blood group P antigens and a differentiation marker in Burkitt lymphoma and other B-cell malignancies.Int. J. Cancer. 42:185-194.
Brooks, G.F. and C.J. Lammel. 1989. Humoral immune response to gonococcal infection.Clin. Micro. Rev.2:S5-S10.
Brossay, L. et al., “Idiotype and Anti-Anti-idiotype Antibodies toNeisseria gonorrhoeaeLipooligosaccharides with Bactericidal Activity but No Cross-Reactivity with Red Blood Cell Antigens”,J. Immunol., 151, pp. 234-243 (1993).
Burritt, J.B., C.W. Bond, K.W. Doss and A.J. Jesiatis. 1996. Filamentous phage display of oligopeptide libraries. Anal. Biochem. 338: 1-13.
CDC. 1991. Pelvic Inflammatory Disease: Guidelines for Prevention and Management.MMWR40:1-25.
CDC. 1982. Sexually transmitted diseases treament guidelines.MMWR31:37S-42S 375-425.
CDC. 1984. Chromosomally mediated resistantNeisseria gonorrhoeae-United States.MMWR33:408-410.
CDC Website. 2000. http://www.cdc.gov
cidod/dastlr/gcdir/Resist/gisp.html.
Cohen, I.R., D.S. Kellogg and L.C. Norins. 1969. Serum antibody response in experimental human gonorrhoeae: immunoglobulins G, A and M. Br. J. Ven. Dis. 45:325-327.
Croix, D. A., J. M. Ahearn, A. M. Rosengard, S. Han, G. Kelsoe, M. Ma, and M. C. Carroll. 1996. Antibody response to a T-dependent antigen requires B cell expression of complement receptors. J. Exp. Med. 183:1857.
Dempsey, P. W., M. E. D. Allison, S. Akkaraju, C. C. Goodnow, and D. T. Fearon. 1996 C3d of complement as a molecular adjuvant: Bridging innate and acquired immunity. Sciences 271: 348.
Densen, P., S. Gulati and P.A. Rice 1987. Specificity of antibodies againstNeisseria gonorrhoeaethat stimulate neutrophil chemotaxis.J. Clin. Invest.80:78-87.
Fischer, M. B., M. Ma, S. Goerg, X. Zhou, J. Xia, X. Zhou, R. G. Howard, T. L. Rothstein, E. Kremmer, F. S. Rosen, and M. C. Carroll. 1996. Regulation of the B cell response to T-dependent antigens by classical Pathway complement. J. Immunol. 157:549.
Fohn, M.J., T.A. Mietzner, T.W. Hubbard, S.A. Morse and E.W. Hook III. 1987. Human immunoglobulin G antibody response to the major gonococcal iron-regulated protein.Infect. Immun.55:3065-3069.
Glynn, A.A. and M.E. Ward. 1970. Nature and heterogeneity of the antigens ofNeisseria gonorrhoeaeinvolved in the serum bactericidal reaction.Infect. Immun.2:162-168.
Gnehm, H.E., S.I. Pelton, S. Gulati and P.A. Rice. 1985. Characterization of antigens from nontypableHaemophilus influenzasrecognized by human bactericidal antibodies.J. Clin. Invest.75:1645-1658.
Griffiss, H.M., J.P. O'Brien, R. Yamasaki, G.D. Williams, P.A. Rice and H. Schneider. 1987. Physical heterogeneity iof Neisserial lipooligosaccharides reflects oligosaccharides that differ in apparent molecular weight, chemical composition, and antigenic expression.Infect. Immun.55:1792-1800.
Gulati, S., D.P. McQuillen, J. Sharon, and P.A. Rice. 1996. Experimental Immunization with a Monoclonal Anti-Idiotope Antibody that Mimics theNeisseria gonorrhoeaeLipooligosaccharide Epitope 2C7. J. Infect. Dis. 174: 1238-48.
Gupta, R.K. and G.R. Siber. 1995. Adjuvants for human vaccines—current status, problems and future prospects. Vaccine 13: 1263-1276.
Gupta, R.K. and G.R. Siber. 1995. Method for quantitation of IgG subclass antibodies in mouse serum by enzyme-linked immunosorbent assay. J. Immunol. Methods 181: 75-81.
Horng, W.J., “Selective Enhancement of a Subpopulation of Anti-Neisseria gonorhoeaeAntibodies in Rabbits Through a Reverse Stimulation by Anti-Idiotype Antibodies”,Fed. Amer. Soc. Exp. Biol., 69th Ann. Meet., Apr. 21-26, 1985 (Anaheim, California), Abstract No. 7502, p. 1694.
Jeme, N.K. 1974. Towards a network theory of the immune system.Ann. Immun. Inst. Pasteur. 125C:373-389.
Joiner, K.A., R. Scales, J.A. Warren, M.M. Frank and P.A. Rice. 1985. Mechanism of action of blocking immunoglobulin G forNeisseria gonorrhoeae. Clin. Invest. 76:1765-1772.
Kasper, D.L., P.A. Rice and W.M. McCormack. 1977. Bactericidal antibody in genital infection due toNeisseria gonorrhoeae. J. Infect. Dis. 135:243-251.
Kennedy, R.C., K. Adler-Storthe, R.D. Henkel, Y. Sanchez, J..L. Melnick nad G.R. Dreesman. 1983. Immune response to hepatitis B surface antigen: enhancement by prior injection of antibodies to the idiotype. Science 221:853-855.
Kennedy, R.C., J.W. Eichberg, R.E. Landford and G.R. Dressman. 1986. Anti-idiotypic vaccine for type B viral hepatitis in chimpanzees.Science232:220-223.
Kennedy, R.C. et al.,BioTechniques, 3, pp. 404-409 (1985).
Kieber-Emmons T. 1998. Peptide mimotopes of carbohydrate antigens. Immunol. Res. 17: 95-108.
Kieber-Emmons, T., R.E. Ward, S. Raychaudhuri, R. Rein, and H. Kohler. 1986. Rational design and application of idiotope vaccines.Int. Rev. Immunol.1:1-26.
Kim, J.J., R.E. Mandrell, H. Zhen, M.A.J. Westerink, J.T. Poolman and J.M. Griffiss. 1988. Electromorphic characterization and description of conserved epitopes of the lipooligosaccharides of group ANeisseria meningitidis. Infect. Immun.56:2631-2638.
Klaus G.G.B., and J. H. Humphrey. 1977. The generation of memory cells I. The role of C3 in the generation of B memory cells. Immunology 33:31.
Lambden, P.R., J.E. Heckels, H. McBride and P.J. Wat

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