Process for the preparation of acid addition salts of 4(5)-methy

Details Process for the preparation of acid addition salts of 4(5)-methy Process for the preparation of acid addition salts of 4(5)-methy

1987-04-27

1988-01-19

Schwartz, Richard A.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D23364

Patent

active

047205520

ABSTRACT:
A new, technologically easily feasible process for the preparation of 4(5)-methyl-5(4)-thiomethyl imidazole of the formula ##STR1## and of acid addition salts thereof is described, wherein 4(5)-methyl-5(4)-bromomethyl imidazole hydrobromide is reacted in an aqueous medium at room temperature with potassium O-ethyl dithiocarbonate to the intermediate O-ethyl-S-(4-methylimidazolyl-5-methyl) dithiocarbonate, which is hydrolyzed at the reflux temperature under nitrogen atmosphere with an aqueous HBr or HCl solution to 4(5)-methyl-5(4)-thiomethyl imidazole hydrobromide or hydrochloride resp.
The compound is a valuable starting material in the synthesis of cimetidine, a well-known drug in the therapy of the ulcer disease.

REFERENCES:
Chemical Abstracts, 91:175352 (1979) [Ger. Offen. 2,855,836, Baudet, et al., 7/12/79].

Affiliated with

Also associated with

Rating

Process for the preparation of acid addition salts of 4(5)-methy does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the preparation of acid addition salts of 4(5)-methy, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the preparation of acid addition salts of 4(5)-methy will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-372176