Amino ceramide-like compounds and therapeutic methods of use

Details Amino ceramide-like compounds and therapeutic methods of use Amino ceramide-like compounds and therapeutic methods of use

2006-12-12

2006-12-12

McKane, Joseph K. (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S210100, C514S315000, C514S237800, C514S408000, C514S428000, C544S162000, C546S233000, C548S568000, C548S579000, C548S950000, C548S954000

Reexamination Certificate

active

07148251

ABSTRACT:
Novel prodrugs of amino ceramide-like compounds are provided which inhibit glucosyl ceramide (GlcCer) formation by inhibiting the enzyme GlcCer synthase, thereby lowering the level of glycosphingolipids. The compounds of the present invention have improved GlcCer synthase inhibition activity and are therefore highly useful in therapeutic methods for treating various conditions and diseases associated with altered glycosphingolipid levels.

REFERENCES:
patent: 5916911 (1999-06-01), Shayman et al.
patent: 5945442 (1999-08-01), Shayman et al.
patent: 5952370 (1999-09-01), Shayman et al.
patent: 6030995 (2000-02-01), Shayman et al.
patent: 6040332 (2000-03-01), Shayman et al.
patent: 6051598 (2000-04-01), Shayman et al.
patent: 10-324671 (1998-12-01), None
patent: 10324671 (1998-12-01), None
patent: WO 9710817 (1997-03-01), None
CAPLUS listing of Accession No. 1985:221199, Keith McCullagh et al, “Carboxyalkyl peptide derivatives.”
Abe, A. et al.,J. Biochem., 111:191-196 (1992).
Alon, R. et al.,J. Immunol., 154:5356-5366 (1995).
Bielawska, A. et al.,FEBS Letters., 307:211-214 (1992).
Blobe, G.C. et al.,Cancer Metastasis Rev., 13:411-431 (1994).
Brenkert, A. et al.,Brain Res., 36:183-193 (1972).
Felding-Habermann, B. et al.,Biochemistry, 29:6314-6322 (1990).
Hakomori, S.,Cancer Cells, 3:461-470 (1991).
Hospattankar, A.V. et al.,Lipids, 17:538-543 (1982).
Inokuchi, J. et al.,Cancer Leters, 38:23-30 (1987).
Inokuchi, J. et al.,Cancer Res., 50:6731-6737 (1990).
Inokuchi, J. et al.,J. Lipid Res., 28:565-571 (1987).
Jaffrézou, J. et al.,Biochim. Biophys. Acta, 1266:1-8 (1995).
Radin, N.S. et al.,Advances in Lipid Research; Sphingolipids in Signaling, Part B., R.M. Bell et al., Ed. (Academic Press, San Diego), 28:183-213 (1993).
Radin, N.S. et al.,NeuroProtocols, A Companion to Methods in Neurosciences, S.K. Fisher et al., Ed., (Academic Press, San Diego), 3:145-155 (1993).
Rosenwald, A.G. et al.,J. Lipid Res., 35:1232-1240 (1994).
Shayman, J.A. et al.,J. Biol. Chem., 266:22968-22974 (1991).
Svensson, M. et al.,Infect. and Immun., 62:4404-4410 (1994).
Zador, I.Z. et al.,J. Clin. Invest., 91:797-803 (1993).
Ziche, M. et al.,Lab. Invest., 67:711-715 (1992).
Lee, L., et al., “Improved Inhibitors of Glucosylceramide Synthase,”Journal of Biological Chemistry, 274(21):14662-14669 (1999).
Gatt, S., et al., “Assay of Enzymes of Lipid Metabolism with Colored and Fluorescent Derivatives of Natural Lipids,”Methods in Enzymology., 72:351-375 (1981).
Inokuchi, et al., “Amino Alcohol Esters as Ceramide Analogs and Pharmaceuticals Containing Them for Treatment of Nerve Diseases,” Abstract of Caplus Accession No. 1998:786189, JP 10324671 (1998).

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