Alternatively spliced isoform of acetyl-CoA carboxylase 2...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S004000, C435S183000, C435S320100, C435S069200, C536S023200

Reexamination Certificate

active

07150969

ABSTRACT:
The present invention features nucleic acids and polypeptides encoding novel splice variant isoforms of acetyl-CoA carboxylase 2 (ACC2). The polynucleotide sequence of ACC2sv1 is provided by SEQ ID NO 3. The amino acid sequence of ACC2sv1 is provided by SEQ ID NO 4. The present invention also provides methods for using ACC2sv1 polynucleotides and proteins to screen for compounds that bind to ACC2sv1.

REFERENCES:
patent: 5480784 (1996-01-01), Kacian et al.
patent: 5616459 (1997-04-01), Kramer et al.
patent: 5849902 (1998-12-01), Arrow et al.
patent: 5852188 (1998-12-01), Cook
patent: 5859221 (1999-01-01), Cook et al.
patent: 6324479 (2001-11-01), Friend et al.
patent: 6485941 (2002-11-01), Waldrop et al.
patent: 6518035 (2003-02-01), Ashby et al.
patent: 2003/0144345 (2003-07-01), Gubler et al.
patent: 2003/0187254 (2003-10-01), Perry et al.
patent: WO 02/079501 (2002-10-01), None
patent: WO 04/013159 (2004-02-01), None
patent: WO 06/004549 (2006-01-01), None
Abe K;Shinohara Y;Terada H; “Isolation and characterization of cDNA encoding rat heart type acetyl-CoA carboxylase” 1998, Biochim Biophys Acta 1398(3):347-352.
Abu-Elheiga L;Almarza-Ortega DB;Baldini A;Wakil SJ; “Human acetyl-CoA carboxylase 2. Molecular cloning, characterization, chromosomal mapping, and evidence for two isoforms” 1997, J Biol Chem 272(16):10669-10677.
Abu-Elheiga L:Brinkley WR;Zhong L;Chirala SS;Woldegiorgis G;Wakil SJ; “The subcellular localization of acetyl-CoA carboxylase 2” 2000, Proc Natl Acad Sci U S A 97(4):1444-1449.
Abu-Elheiga L;Jayakumar A;Baldini A;Chirala SS;Wakil SJ; “Human acetyl-CoA carboxylase: characterization, molecular cloning, and evidence for two isoforms” 1995, Proc Natl Acad Sci U S A 92(9):4011-4015.
Abu-Elheiga L;Matzuk MM;Abo-Hashema KA;Wakil SJ; “Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2” 2001, Science 291(5513):2613-2616.
Abu-Elheiga L;Oh W;Kordari P;Wakil SJ; “Acetyl-CoA carboxylase 2 mutant mice are protected against obesity and diabetes induced by high-fat/high-carbohydrate diets” 2003, Proc Natl Acad Sci U S A 100(18):10207-10212.
Barber MC;Price NT;Travers MT; “Structure and regulation of acetyl-CoA carboxylase genes of metazoa” 2005, Biochim Biophys Acta 1733(1):1-28.
Bernstein E;Caudy AA;Hammond SM;Hannon GJ; “Role for a bidentate ribonuclease in the initiation step of RNA interference” 2001, Nature 409(6818):363-366.
Bianchi A;Evans JL:Iverson AJ;Nordlund AC;Watts TD;Witters LA; “Identification of an isozymic form of acetyl-CoA carboxylase” 1990, J Biol Chem 265(3):1502-1509.
Cramer CT;Goetz B;Hopson KL;Fici GJ;Ackermann RM;Brown SC;Bisgaier CL;Rajeswaran WG;Oniciu DC;Pape ME; “Effects of a novel dual lipid synthesis inhibitor and its potential utility in treating dyslipidemia and metabolic syndrome” 2004, J Lipid Res 45(7):1289-1301.
Davies SP;Sim AT;Hardie DG; “Location and function of three sites phosphorylated on rat acetyl-CoA carboxylase by the AMP-activated protein kinase” 1990, Eur J Biochem 187(1):183-190.
den Boer ME;Dionisi-Vici C;Chakrapani A;van Thuijl AO; Wanders RJ;Wijburg FA; “Mitochondrial trifunctional protein deficiency; a severe fatty acid oxidation disorder with cardiac and neurologic involvement” 2003, J Pediatr 142(6):684-689.
Dyck JR;Lopaschuk GD; “Malonyl CoA control of fatty acid oxidation in the ischemic heart” 2002, J Mol Cell Cardiol 34(9):1099-1109.
Elbashir SM;Harborth J;Lendeckel W; Yalcin A; Weber K;Tuschl T; “Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells” 2001, Nature 411(6836):494-498.
Fire A;Xu S;Montgomery MK;Kostas SA;Driver SE;Mello CC; “Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans” 1998, Nature 391 (6669):806-811.
Florea L;Hartzell G;Zhang Z;Rubin GM;Miller W; “A computer program for aligning a cDNA sequence with a genomic DNA sequence” 1998, Genome Res 8(9):967-974.
Gregersen N;Bross P;Andresen BS; “Genetic defects in fatty acid beta-oxidation and acyl-CoA dehydrogenases. Molecular pathogenesis and genotype-phenotype relationships” 2004, Eur J Biochem 271(3):470-482.
Guertl B;Noehammer C;Hoefler G; “Metabolic cardiomyopathies” 2000, Int J Exp Pathol 81(6);349-372.
Ha J;Lee JK;Kim KS;Witters LA;Kim KH; “Cloning of human acetyl-CoA carboxylase-beta and its unique features” 1996, Proc Natl Acad Sci U S A 93(21):11466-11470.
Hamilton AJ;Baulcombe DC; “A species of small antisense RNA in posttranscriptional gene silencing in plants” 1999, Science 286(5441):950-952.
Hammond SM;Boettcher S;Caudy AA;Kobayashi R;Hannon GJ; “Argonaute2, a link between genetic and biochemical analyses of RNAi” 2001, Science 293(5532):1146-1150.
Hardie DG; Hawley SA; “AMP-activated protein kinase: the energy charge hypothesis revisited” 2001, Bioessays 23(12):1112-1119.
Harwood HJ;Petras SF;Shelly LD;Zaccaro LM;Perry DA;Makowski MR;Hargrove DM;Martin KA;Tracey WR;Chapman JG;Magee WP;Dalvie DK:Soliman VF;Martin WH;Mularski CJ;Eisenbeis SA; “Isozyme-nonselective N-substituted bipiperidylcarboxamide acetyl-CoA carboxylase inhibitors reduce tissue malonyl-CoA concentrations, inhibit fatty acid synthesis, and increase fatty acid oxidation in cultured cells and in experimental animals” 2003, J Biol Chem 278(39):37099-37111.
Kafert S;Krauter J;Ganser A;Eder M; “Differential quantitation of alternatively spliced messenger RNAs using isoform-specific real-time RT-PCR” 1999, Anal Biochem 269(1):210-213.
Kan Z;Rouchka EC;Gish WR;States DJ; “Gene structure prediction and alternative splicing analysis using genomically aligned ESTs” 2001, Genome Res 11(5):889-900.
Kan Z;States D;Gish W; “Selecting for functional alternative splices in ESTs” 2002, Genome Res 12(12):1837-1845.
Kennerdell JR;Carthew RW; “Use of dsRNA-mediated genetic interference to demonstrate that frizzled and frizzled 2 act in the wingless pathway” 1998, Cell 95(7):1017-1026.
Kim KH; “Regulation of mammalian acetyl-coenzyme A carboxylase” 1997, Annu Rev Nutr 17(0):77-99.
Kohler G;Milstein C; “Continuous cultures of fused cells secreting antibody of predefined specificity” 1975, Nature 256(5517):495-497.
Kudo N;Barr AJ;Barr RL;Desai S;Lopaschuk GD; “High rates of fatty acid oxidation during reperfusion of ischemic hearts are associated with a decrease in malonyl-CoA levels due to an increase in 5′-AMP-activated protein kinase inhibition of acetyl-CoA carboxylase” 1995, J Biol Chem 270(29):17513-17520.
Lee JJ;Moon YA;Ha JH;Yoon DJ;Ahn YH;Kim KS; “Cloning of human acetyl-CoA carboxylase beta promoter and its regulation by muscle regulatory factors” 2001, J Biol Chem 276(4):2576-2585.
Minokoshi Y;Kim YB;Peroni OD;Fryer LG;Muller C;Carling D;Kahn BB; “Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase” 2002, Nature 415(6869);339-343.
Mironov AA;Fickett JW;Gelfand MS; “Frequent alternative splicing of human genes” 1999, Genome Res 9(12):1288-1293.
Misquitta L;Paterson BM; “Targeted disruption of gene function in Drosophila by RNA interference (RNA-i): a role for nautilus in embryonic somatic muscle formation” 1999, Proc Natl Acad Sci U S A 96(4):1451-1456.
Modrek B;Resch A;Grasso C;Lee C; “Genome-wide detection of alternative splicing in expressed sequences of human genes” 2001, Nucleic Acids Res 29(13):2850-2859.
Moller DE; “New drug targets for type 2 diabetes and the metabolic syndrome” 2001, Nature 414(6865):821-827.
Munday MR;Hemingway CJ; “The regulation of acetyl-CoA carboxylase—a potential target for the action of hypolipidemic agents” 1999, Adv Enzyme Regul 39(0):205-234.
Oh SY;Park SK;Kim JW; Ahn YH;Park SW;Ki

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Alternatively spliced isoform of acetyl-CoA carboxylase 2... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Alternatively spliced isoform of acetyl-CoA carboxylase 2..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Alternatively spliced isoform of acetyl-CoA carboxylase 2... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3717683

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.