Medicines in controlling Vpr function

Details Medicines in controlling Vpr function Medicines in controlling Vpr function

2006-12-12

2006-12-12

Saeed, Kamal A. (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S351000, C546S290000, C546S329000

Reexamination Certificate

active

07148244

ABSTRACT:
A Vpr function regulating composition useful in the treatment of subjects infected with HIV or having AIDS, wherein the composition comprises an aminostilbazole derivative represented by the following formula [1] or a salt thereof as an active ingredient:in-line-formulae description="In-line Formulae" end="lead"?A-B-D-E[1]in-line-formulae description="In-line Formulae" end="tail"?wherein A represents heteroaryl or an oxide thereof, B represents ethenylene, D represents phenylene, and E represents the formula: —N(R)—SO2-G wherein G represents phenyl, R represents hydrogen, alkyl, or —COR0(R0represents alkyl, alkoxy, aryloxy, 5- to 6-membered heteroaryl, heteroarylmethyl, aminoalkylene, or cyclic amino alkylene)or the like.

REFERENCES:
patent: 754682 (1997-01-01), None
patent: 2001 261649 (2001-09-01), None
patent: WO 95/31901 (1995-11-01), None
patent: WO 96/19437 (1996-06-01), None
patent: WO 01/21598 (2001-03-01), None
Human Immunodeficiency Virus Type 1 Vpr Induces Apoptsis Through Caspase Activation Journal of Virology, Apr. 2002, vol. 74, No. 7, pp. 3105-3111.
C.K. Arunagiri, et al., A C-Terminal Domain of HIV-1 Accessory Protein Vpr is Involved in Penetration, Mitochondrial Dysfunction and Apoptosis of Human CD4+ Lymphocytes, Apoptosis 2, 69-76 (1997).
I.G. Macreadie, et al., A Domain of Human Immunodeficiency Virus Type 1 Vpr Containing Repeated H(S/F)RIG Amino Acid Motifs Causes Cell Growth Arrest and Structural Defects, Proc. Natl. Acad. Sci. USA 92, 2770-2774 (1995).
S.C. Piller, et al., Extracellular HIV-1 Virus Protein R Causes a Large Inward Current and Cell Death in Cultured Hippocampal Neurons: Implications for AIDS Pathology, Proc. Natl. Acad. Sci. USA 95, 4595-4660 (1998).
Derwent publication-abstract of JP2001 261649A.
Nishizawa, et. al. “Induction of Apoptosis by the Vpr Protein of Human Immunodeficiency Virus Type 1 Occurs Independently of G2 Arrest of the Cell Cycle”; Virology, 276, 16-26 (2000).

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