Cilostazol preparation

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Capsules

Reexamination Certificate

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Details

C424S455000, C424S463000, C424S465000, C424S474000, C424S489000, C424S490000, C514S951000, C514S952000, C514S960000, C514S961000, C514S962000, C514S963000, C514S964000

Reexamination Certificate

active

07144585

ABSTRACT:
Provided is a cilostazol preparation which comprises incorporating a fine powder of cilostazol into a dispersing and/or solubilizing agent thereby to enhance the dispersibility and/or solubility. Further, provided is a process for improving absorbability of a slightly soluble drug such as cilostazol even at the lower portion of the digestive tract, wherein said drug is hard to be absorbed at the lower portion of the digestive tract when a conventional method is used. According to the present invention, cilostazol is absorbed enough even at the lower portion of the digestive tract to have an effect as thrombolytic drug, cerebral circulation improving drug or the like.

REFERENCES:
patent: 4344934 (1982-08-01), Martin et al.
patent: 4892741 (1990-01-01), Ohm et al.
patent: 4895726 (1990-01-01), Curtet et al.
patent: 5145684 (1992-09-01), Liversidge et al.
patent: 5202129 (1993-04-01), Samejima et al.
patent: 5624683 (1997-04-01), Andoh et al.
patent: 5849330 (1998-12-01), Marvola et al.
patent: 6117455 (2000-09-01), Takada et al.
patent: 6264922 (2001-07-01), Wood et al.
patent: 6294192 (2001-09-01), Patel et al.
patent: 6825214 (2004-11-01), Mendelovici et al.
patent: 2005/0255155 (2005-11-01), Sen et al.
patent: 0 179 583 (1986-04-01), None
patent: 0 661 045 (1995-05-01), None
patent: 7-291869 (1995-11-01), None
patent: 10-67657 (1998-03-01), None
patent: WO 93/05770 (1993-04-01), None
patent: WO 96/21448 (1996-07-01), None
patent: WO 97/48382 (1997-12-01), None
patent: WO PCT 97/18382 (1997-12-01), None
patent: WO 98/31360 (1998-07-01), None
“Pharmacokinetics vol. 13, Supplement (1998), S 169, 11B16-4 Analysis of mechanism on improving mucosa lesion caused by intermediate chain-fatty acid salt according to amino acid,” with English translation.
“Bronchoprotective Effect of an Intrabronchial Administration of Cilostazol Powder and a Nebulized PDE1 and PDE4 Inhibitor KF19514 in Guinea Pigs,” M. Fujimura et al., International Archives of Allergy and Immunology, vol. 116, No. 3, 1998, pp. 220-227.
“Pharmazeutisch-technologische,” H. Sucker et al.. 1991, Thieme Verlag., Stuttgart XP002145328 189560, pp. 673-675.
Carmona-Ibáñez, Gisela et al., “Experimental Studies on the Influence of Surfactants on Intestinal Absorption of Drugs”, Arzneim.Forsch./Drug Res. 49(I), Nr. 1 pp. 44-50, (1999).
Sancho-Chust, V. et al., “Experimental Studies on the Influence of Surfactants on Intestinal Absorption of Drugs”, Arzneim.Forsch./Drug Res. 45(I), Nr. 5 pp. 595-601, (1995).
Garrigues, T.M. et al., “Absorption-partition Relationships for True Homologous Series of Xenobiotics as a Possible Approach to Study Mechanisms of Surfactants in Absorption. Iv. Phenylacetic Acid Derivatives”, International Journal of Pharmaceutics, 79 pp. 135-140, (1992).

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