Homopiperidine derivatives as NK-1 antagonists

Details Homopiperidine derivatives as NK-1 antagonists Homopiperidine derivatives as NK-1 antagonists

2006-08-29

2006-08-29

Coleman, Brenda (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C540S609000, C540S610000

Reexamination Certificate

active

07098203

ABSTRACT:
The present disclosure relates to chemical compounds and their use in human therapy. In a specific embodiment, compounds of Formula (I) or an isomer, a pharmaceutically acceptable salt or solvate thereof or a pharmaceutically acceptable formulation comprising said compoundsuseful for the treatment or prevention of conditions mediated by tachykinins and/or selective inhibition of serotonin reuptake transporter protein. The compounds act as dual NK-1 antagonists and selective serotonin reuptake inhibitors.

REFERENCES:
patent: 6136824 (2000-10-01), MacLeod et al.
patent: WO 2004/005255 (2004-01-01), None
patent: WO 2004/005256 (2004-01-01), None
Kramer, Mark S., et al., “Distinct Mechanism for Antidepressant Activity by Blockade of Central Substance P Receptors”,Science, 281 (1998) 1640-1645.
Maubach, Karen A., et al., “Novel Strategies for Pharmacotherapy of Depression”,Current Opinion in Chemical Biology, 3 (1999) 481-488.
Rosen, Terry J., et al., “Synthesis and Structure-Activity Relationships of CP-122,721, A Second-Generation NK-1 Receptor Antagonist”, ,Bioorganic&Medicinal Chemistry Letters, 8 (1998) 281-284.
Ryckmans, Thomas, et al., “First Dual NK1Antagonists-Serotonin Reuptake Inhibitors: Synthesis and SAR of a New Class of Potential Antidepressants”,Bioorganic&Medicinal Chemistry Letters, 12 (2002) 261-264.

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