Treatment of hypertension

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C549S200000, C549S415000

Reexamination Certificate

active

07122574

ABSTRACT:
Polyphenol-containing compositions, for example procyanidins and derivatives thereof, and their use for treating hypertension are disclosed. Compositions may be used for human and veterinary use, and may be, for example, in a form of a food, a dietary supplement or a pharmaceutical.

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Inokuchi, Jin-ichi, et al.,Antihypertensive Substance in Seeds of Areca Catechu L., Life Sciences, vol. 38, pp. 1375-1382 (1986).
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Andriambeloson, Emile,Nitric Oxide Production and Endothelium-dependent Vasorelaxation Induced by Wine Polyphenols in Rat Aorta, British Journal of Pharmacology, vol. 120, pp. 1053-1058 (1997).
Sanz, M.J., et al.,Isolation and Hypotensive Activity of a Polymeric Procyanidin Fraction from Pistacia Lentiscus L., Pharmazie, vol. 47, pp. 466-467 (1992).
Cheng, Juei-Tang, et al.,Antihypertensive Principles from the Leaves of Melastoma Candidum, Planta Media Journal of Medicinal Plant Research, vol. 59, pp. 405-407 (1993).
Fitzpatrick, David et al.,Endothelium-dependent Vasorelaxing Activity of Wine and Other Grape Products, Am. J. Physiol. 265(Heart Circ. Physiol. 34) H774-H778 (1993).
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