Thiophene carboxamide compounds as inhibitors of enzyme IKK-2

Details Thiophene carboxamide compounds as inhibitors of enzyme IKK-2 Thiophene carboxamide compounds as inhibitors of enzyme IKK-2

2006-10-24

2006-10-24

Saeed, Kamal A. (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C546S281400

Reexamination Certificate

active

07125896

ABSTRACT:
The invention relates to thiophene carboxanmides of formula (I), wherein A, R1, R2, R3, n and X are as defined in the specification, processes and intermediates used in their preparation, pharmaceutical compositions containing them and their use in therapy.

REFERENCES:
patent: 6048880 (2000-04-01), Kawai et al.
patent: 2002/0002199 (2002-01-01), Jeppesen et al.
patent: 2002/0107252 (2002-08-01), Baxter et al.
patent: 2004/0024047 (2004-02-01), Callahan et al.
patent: 2004/0235821 (2004-11-01), Griffiths et al.
patent: 2006/0058522 (2006-03-01), Faull
patent: 0853083 (1998-07-01), None
patent: 0 908 456 (1999-04-01), None
patent: 1468012 (1977-03-01), None
patent: 2195634 (1988-04-01), None
patent: WO 98/02430 (1998-01-01), None
patent: WO 98/54116 (1998-12-01), None
patent: WO 99/46244 (1999-09-01), None
patent: WO 9946244 (1999-09-01), None
patent: WO 0071532 (2000-11-01), None
patent: WO 200158890 (2001-08-01), None
patent: WO 0198290 (2001-12-01), None
patent: WO 200198290 (2001-12-01), None
patent: WO 0230353 (2002-04-01), None
patent: WO 03/010158 (2003-02-01), None
patent: WO 2003028731 (2003-04-01), None
patent: WO 2003029241 (2003-04-01), None
patent: WO 2004/063185 (2004-07-01), None
patent: WO 2004/063186 (2004-07-01), None
Chen, Guoqing and Goeddel, David, “TNF-R1 Signaling: A Beautiful Pathway,” Science, vol. 296, pp. 1634-1635 (May 31, 2002) at p. 1634, col. 1, lines 9-19, lines 32-36 and Figure 1; also p. 1635, col. 1, lines 2-17.
Awada, A., et al., “The pipeline of new anticancer agents for breast cancer treatment in 2003,” Critical Reviews in Oncology/Hematology, vol. 48, pp. 45-63 at p. 46, 2nd column, line 3, et seq.
Compston, A., and Coles, A., “Multiple sclerosis,” The Lancet, vol. 359, pp. 1221-1231 (Apr. 6, 2002), at p. 1224, col. 2, lines 21 et seq. (causes of M.S.); p. 1226, lines 10 et seq. (treatment of M.S.); and p. 1221, lines 18-36.
Hartung, H., et al., “What do we know about the mechanism of action of disease-modifying treatments in MS?” J. Neurol., vol. 251(suppl. 5), pp. V/12-V/29 (2004), at p. V/13, lines 26-30; and p. V/16, col. 2, lines 3-10.
Zayed et al., “Studies on 5-Aminopyrazole Derivatives. Synthesis of Some New Fused Pyrazole Derivatives”,Monatshefte für Chemie115:431-436 (1984).
U.S. Appl. No. 09/868,884, filed Feb. 5, 2002, Baxter et al.
U.S. Appl. No. 10/484,645, filed Jan. 22, 2004, Griffiths et al.

Affiliated with

Also associated with

Rating

Thiophene carboxamide compounds as inhibitors of enzyme IKK-2 does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Thiophene carboxamide compounds as inhibitors of enzyme IKK-2, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Thiophene carboxamide compounds as inhibitors of enzyme IKK-2 will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3711785