N-(3-(4-substituted-1-piperidinyl)-1-phenylpropyl)...

Details N-(3-(4-substituted-1-piperidinyl)-1-phenylpropyl)... N-(3-(4-substituted-1-piperidinyl)-1-phenylpropyl)...

2006-12-26

2006-12-26

Chang, Celia (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S255030, C514S256000, C514S319000, C514S320000, C514S324000, C546S192000, C546S195000, C546S196000, C546S205000, C546S207000, C546S211000, C544S333000, C544S336000

Reexamination Certificate

active

07153868

ABSTRACT:
The present invention provides a method of treatment of a subject suffering from a disease, such as schizophrenia, for which the administration of an NK-3 antagonist is indicated which comprises administering to that subject a therapeutically effective amount of a compound of formula I:wherein, generally,Q isR1is benzyl, phenyl, thiophene or imidazolyl optionally substituted with C1-4alkyl or halogen, such as methyl, fluorine or bromine;R2is hydrogen or C1-4alkyl such as methyl;R3is phenyl;R4is hydrogen;R5is hydrogen or C1-6alkylcarbonyl such as methylcarbonyl;X is —SO2— or —C(O)N(R2)SO2— where R2is preferably hydrogen;Y is a bond, CH2or Z1where Z1is —N(Rf)— in which Rfis C1-6alkylcarbonyl such as ethylcarbonyl; andR6is phenyl, pyrazolyl, pyridyl, pyrimidinyl or benzimidazolonyl optionally substituted with one or two groups chosen from C1-6alkyl and benzyl, such as methyl, ethyl and benzyl;or a pharmaceutically acceptable salt thereof.

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Fouget et al. “4-benzylpiperidine sigma receptor ligands” CA 120:163993 (1994).
Chambers et al. “Preparation of N-(3-(4-substituted piperidin . . . ” CA 140:77142.
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