Ligand precursors for incorporation into peptides

Details Ligand precursors for incorporation into peptides Ligand precursors for incorporation into peptides

1996-09-05

1998-08-25

Tsang, Cecilia J.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Synthesis of peptides

530334, 530335, 530339, 530345, C07K 100

Patent

active

057984441

ABSTRACT:
Compositions and methods of incorporating ligand precursors and ligands at any location within a peptide during peptide synthesis are disclosed. Derivatives of 2,4,5-triaminopentanoic acid and .gamma.-aminoglutamic acid are selectively incorporated into the peptide during solid phase or liquid phase synthesis, depending upon the choice of protecting groups. Ligand synthesis may then be completed at a later time to produce N.sub.3 S, N.sub.2 S.sub.2, and EDTA type chelating agents.

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patent: 5094950 (1992-03-01), Kondo
R. Arya et al., "Rapid Synthesis and Introduction of a Protected EDTA-like Group during the Solid-Phase Assembly of Peptides", Bioconjugate Chem., 1991, vol. 1, pp. 323-326.
Altman et al., "Bifunctional Chelating Agetns. Part 2. Synthesis of 1-(2-Carboxyethyl)ethylenediaminetetra-acetic Acid by Ring Cleavage of a Substituted Imidazole", J. Chem. Soc., Perkin Trans, 1984, pp. 59-62.
Altman et al., "Ring Opening of N-Tosylhistamine with Di-t-butyl Pyrocarbonate: Synthesis of 1,2-Diamino-4-tosylaminobutane Dihydrochloride", Chem. Soc., Chem. Commun., 1985, pp. 1133-1134.
Kolodziejczyk, Int J Pept Prot Res. 39, 382, 1992.

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