Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1980-03-25
1981-08-18
Waltz, Thomas A.
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
2603457R, 2603473, 564211, 564214, C07C103375, C07D30506, C07D30706, C07D30904
Patent
active
042845645
ABSTRACT:
The present invention is directed to a process for the preparation of certain N-substituted-2-haloacetanilides via the reaction of a secondary 2-haloacetanilide with a haloalkyl ether, particularly, halomethyl ethers, which comprises forming the ether in situ by the in-solvent reaction of an alcohol, formaldehyde or other aldehyde and an acid halide to produce high purity haloalkyl ethers, while decreasing the concentration of undesirable bis by products, as for example bis(chloromethyl) ether. The ether formed in situ thereafter reacts with the secondary 2-haloacetanilide in the presence of a phase transfer catalyst and base to form the N-substituted-2-haloacetanilide.
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Hubele, CA 90:87084k, (1979).
Monsanto Co., CA 67:99832r, (1967).
Alt Gerhard H.
Chupp John P.
Coburn Patricia A.
Monsanto Company
Peterson Donald W.
Waltz Thomas A.
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