Process for preparing optically active phenylalanine

Details Process for preparing optically active phenylalanine Process for preparing optically active phenylalanine

1984-07-25

1985-09-17

Trousof, Natalie

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

562443, C07B 1900

Patent

active

045422362

ABSTRACT:
The present invention relates to a process for preparing optically active phenylalanine which comprises resolving mixture of a complex of D-phenylalanine and optically active mandelic acid and a complex of L-phenylalanine and optically active mandelic acid in a solvent containing hydrochloric acid, carboxylic acid, phosphoric acid or a salt thereof to obtain the complex having lower solubility, and removing said optically active mandelic acid from the obtained complex to obtain an optically active phenylalanine.
In the case of resolving DL-phenylalanine by the process according to the present invention, the amount of mother liquor used in resolution can be made to about 1/2 to 1/6 as compared to the amount of mother liquor of which the acidic compound or the salt thereof is not used in the resolution. Accordingly, the process according to the present invention is extremely profitable as an industrial process for producing an optically active phenylalanine.

REFERENCES:
patent: 4151198 (1979-04-01), Halmos
patent: 4198524 (1980-04-01), Tashiro et al.
Koga et al: "Asymmetric Interaction Between Mandelic Acid and Aromatic .alpha.-Amino Acids in Aqueous System." Nippon Kagaku Zasshi, 92(11), 999-1002, (1971) with translation.
Chemical Abstracts, vol. 77, 19976j, (1972).

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