Treatment of hepatic fibrosis with imatinib mesylate

Details Treatment of hepatic fibrosis with imatinib mesylate Treatment of hepatic fibrosis with imatinib mesylate

2006-06-20

2006-06-20

Henley, III, Raymond J. (Department: 1614)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

07064127

ABSTRACT:
Disclosed herein is a method for treating hepatic fibrosis comprising administering to a patient in need of such treatment an amount effective to treat hepatic fibrosis of imatinib mesylate. This is based on the ability of imatinib mesylate to down regulate stellate cell activation in culture and in vivo. Hepatic fibrosis is not limited to patients with chronic Hepatitis B, Hepatitis C, non-alcoholic steatophepatitis (NASH), alcoholic liver disease, metabolic liver diseases (Wilson's disease, hemochromatosis), biliary obstruction (congenital or acquired) or liver diseases associated with fibrosis of unknown cause.

REFERENCES:
patent: 6872715 (2005-03-01), Santi et al.
patent: 2003/0147813 (2003-08-01), Lyons
patent: 2003/0203846 (2003-10-01), Srivastava et al.
patent: 2004/0121971 (2004-06-01), Chen et al.
patent: 2005/0261283 (2005-11-01), Sukhatme
Kinnman, Laboratory Investigation, vol. 83, No. 2, Feb. 2003, “The Myofibroblastic Conversion of Peribiliary Fibrogenic Cells Distinct from Hepatic Stellate Cells is Stimulated by Platelet-Derived Growth Factor During Liver Fibrogenesis”, pp. 163-173.

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