Method of preparing cow brain homogenate

Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing

Reexamination Certificate

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C424S147100, C435S007100, C435S070100, C435S071100, C436S503000, C436S518000, C436S547000, C530S387100

Reexamination Certificate

active

07087213

ABSTRACT:
A method of isolating and detecting the presence of a disease related conformation of a protein (e.g., PrPSc) is disclosed. The sample is treated such as by contacting it with a protease and then contacting the treated sample with a binding partner which binds the PrPScwhich can be isolated and separated from the sample.

REFERENCES:
patent: 4806627 (1989-02-01), Wisniewski et al.
patent: 5565186 (1996-10-01), Prusiner et al.
patent: 6214565 (2001-04-01), Prusiner et al.
patent: 6406864 (2002-06-01), Prusiner et al.
patent: 6677125 (2004-01-01), Prusiner et al.
patent: WO 93/10227 (1993-05-01), None
patent: WO 97/43649 (1997-11-01), None
patent: WO 98/37210 (1998-08-01), None
patent: WO 99/42487 (1999-08-01), None
Anderson et al., (1996) ATransmission dynamics and epidemiology of BSE in British cattle,@Nature382: 779-88.
Barry, R.A., et al., (1986) “Monoclonal Antibodies to the Cellular and Scrapie Prion Proteins,”Journal of Infectious Diseases154:518-521.
Basler et al., (1986) “Scrapie and Cellular PrP Isoforms Are Encoded by the Same Chromosomal Gene,”Cell46: 417-28.
Bendheim, et al., (1984) “Antibodies to a Scrapie Prion Protein,”Nature310:418-421.
Bode et al., (1985) “Characterization of Antisera Against Scrapie-Associated Fibrils (SAF) from Affected Hamster and Cross-Reactivity with SAF from Scrapie-Affected Mice and from Patients with Creutzfeldt-Jacob Disease,”J. Gen. Virol. 66:2471-2478.
Bolton et al., (1982) “Identification of a Protein That Purifies with the Scrapie Prion,”Science218: 1309-11.
Brown et al., (1992) “‘Friendly Fire’ in Medicine: Hormones, Homografts, and Creutzfeldt-Jakob Disease,”Lancet340: 24-27.
Buchanan et al., (1991) “Mortality, Neoplasia, and Creutzfeldt-Jakob Disease in Patients Treated with Human Pituitary Growth Hormone in the United Kingdom”,BMJ302:824-828.
Bueler et al., (1992) “Normal Development and Behavior of Mice Lacking the Neuronal Cell-surface PrP Protein,”Nature356:577-582.
Carter, et al., (1992) AHigh LevelEscherichia coliExpression and Production of a Bivalent Humanized Antibody Fragment,@Biotechnology10:163-7.
Cochius et al., (1992) “Creutzfeldt-Jakob Disease in a Recipient of Human Pituitary-Derived Gonadotrophin: A Second Case,”J. Neurol. Neurosurg. Psychiatry55:1094-1095.
Cochius et al., (1990) “Creutzfeldt-Jakob Disease in a Recipient of Human Pituitary-Derived Gonadotrophin,”Aust. N.Z. J. Med. 20:592-593.
Collinge, et al., (1996) APrion protein gene analysis in new variant cases of Creutzfeldt-Jakob disease,@Lancet348:56.
Gajdusek, D.C., (1977) “Unconventional Viruses and the Origin and Disappearance of Kuru,”Science197:943-960.
Gibbs, Jr. et al., (1993) “Creutzfeldt-Jakob Disease Infectivity of Growth Hormone Derived from Human Pituitary Glands,”N. Engl. J. Med. 328:358-359.
Goldfarb et al., (1992) “FatalFamilial insomniaand Familial Creutzfeldt-Jakob Disease: Disease Phenotype Determined by a DNA Polymorphism,”Science258:806-808.
Goldman, W. “PrP gene and its association with spongiform encephalopathies,”British Medical Bulletin(Oct. 1993) 49(4) :839-59 (Abstract).
Healy et al., “Creutzfeldt-Jakob Disease After Pituitary Gonadotrophins: The Prion is the Problem,”BMJ(1993) 307:517-518.
Hsiao et al., (1994) ASerial transmission in rodents of neurodegeneration from transgenic mice expressing mutant rion protein,@Proc. National Acad. Sci. USA91:9126-30.
Kascsak, R.J., et al., (1987) “Mouse Polyclonal and Monoclonal Antibody to Scrapie-Associated Fibril Proteins,”Journal of Virology61:3688-3693.
Lasmezas et al., (1993) “Recombinant Human Growth Hormone and Insulin-Like Growth Factor I Induce PRP Gene Expression in PC12 Cell,”Biochem. Biophys. Res. Commun. 196:1163-1169.
McKinley et al., (1983) “A Protease-Resistant Protein is a Structural Component of the Scrapie Prion,”Cell35:57-62.
Mehlhorn et al., (1996) AHigh-Level Expression and Characterization of a Purified 142-Residue Polypeptide of the Prion Protein,@Biochemistry35:5528-37.
Meyer et al., (1986) “Separation and Properties of Cellular and Scrapie Prion Proteins,”Proc. Natl. Acad. Sci. USA83: 2310-2314.
Oesch, et al., (1985) “A Cellular Gene Encodes Scrapie PrP 27-30 Protein,”Cell40: 735-46.
Pan, et al., (1993) AConversion of α-helics into β-sheets features in the formation of the scrapie prion proteins,@Proc. Natl. Acad. Sci. USA90:10962-66.
Pan, et al., (1992) “Purification and Properties of the Cellular Prion Protein from Syrian Hamster Brain,”Protein Sci. 1:1343-1352.
Prusiner, S.B., et al., (1983) “Scrapie prions aggregate to form amyloid-like birefringent rods,”Cell35: 349-58.
Prusiner, S.B. et al., ABiology of Prions,@The Molecular and Genetic Basis of Neurological Disease, 2nd Edition, Chap. 7, pp. 103-143.
Rogers et al., (1991) “Epitope Mapping of the Syrian Hamster Prion Protein Utilizing Chimeric and Mutant Genes in a Vaccinia Virus Expresion System,”J. Immunol. 147: 3568-74.
Rogers, et al., (1993) AConversion of truncated and elongated prion proteins into the scrapie isoform in cultured cells,@Proc. Natl. Acad. Sci. USA90:3182-6.
Safar et al. J., (1993) AConformational Transitions, Dissociation, and Unfolding of Scrapie Amyloid (Prion) Protein,@J. Biol. Chem. 268: 20276-84.
Safar, et al., (1990) AScrapie-associated precursor proteins: Antigenic relationship between species and immunocytochemical localization in normal, scrapie, and Creutzfeldt-Jakob disease brains,@Neurology40: 513-7.
Schmerr, Mary Jo et al., (1996) “Improvements in a Competition Assay to Detect Scrapie Prion Protein by Capillary Eletrophoresis”,Journal of Chromatography B681:29-35.
Serban et al, (1990) “Rapid Detection of Creuzfeldt-Jakob Disease and Scrapie Prion Proteins,”Neurology40:110-7.
Stahl et al., (1993) AStructural Studies of the Scrapie Prion Protein Using Mass Spectrometry and Amino Acid Sequencing,@Biochemistry32: 1991-2002.
Taraboulos et al., (1992) “Regional Mapping of Prion Proteins in Brain,”Proc. Natl. Acad. Sci. USA89:7620-7624.
Turk, et al., (1988) “Purification and Properties of the Cellular and Scrapie Hamster Prion Proteins,”Eur. J. Biochem. 176:21-30.
Wilesmith and Wells, (1991) ABovine Spongiform Encephalopathy,@Curr. Topics Microbiol. Immunol. 172 21-38.
Wilesmith, ABovine Spongiform Encephalopathy,169Methods in Molecular Medicines: Prion Diseases, pp. 155-73.
Williamson, et al., (1996) ACircumventing tolerance to generate autologous monoclonal antibodies to the prion protein,@Proc. Natl. Acad. Sci. USA93: 7279-82.
Yokoyama, Takashi, et al., (1996) “Immunoreactivity of Specific Epitopes of PrPscis Enhanced by Pretreatment in a Hydrated Autoclave”,Clinical and Diagnostic Laboratory Immunology3(4):470-471.

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