Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2006-11-07
2006-11-07
Balasubramanian, Venkataraman (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C544S405000, C544S406000, C544S408000
Reexamination Certificate
active
07132424
ABSTRACT:
This invention provides compounds defined by Formula Iin-line-formulae description="In-line Formulae" end="lead"?R1-Q-D-(V1)m—R2Iin-line-formulae description="In-line Formulae" end="tail"?or a pharmaceutically acceptable salt thereof,wherein R1, Q, D, V1, m, and R2are as defined in the specification. The invention also provides pharmaceutical compositions comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, as defined in the specification, together with a pharmaceutically acceptable carrier, diluent, or excipient. The invention also provides methods of inhibiting an MMP-13 enzyme in an animal, comprising administering to the animal a compound of Formula I, or a pharmaceutically acceptable salt thereof. The invention also provides methods of treating a disease mediated by an MMP-13 enzyme in a patient, comprising administering to the patient a compound of Formula I, or a pharmaceutically acceptable salt thereof, either alone or in a pharmaceutical composition. The invention also provides methods of treating diseases such as heart disease, multiple sclerosis, osteo- and rheumatoid arthritis, arthritis other than osteo- or rheumatoid arthritis, cardiac insufficiency, inflammatory bowel disease, heart failure, age-related macular degeneration, chronic obstructive pulmonary disease, asthma, periodontal diseases, psoriasis, atherosclerosis, and osteoporosis in a patient, comprising administering to the patient a compound of Formula I, or a pharmaceutically acceptable salt thereof, either alone or in a pharmaceutical composition. The invention also provides combinations, comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, together with another pharmaceutically active component as described in the specification.
REFERENCES:
patent: 2650223 (1953-08-01), Zaugg et al.
patent: 5130317 (1992-07-01), Baader et al.
patent: 5260323 (1993-11-01), Baader et al.
patent: 5519038 (1996-05-01), Baader et al.
patent: 6008243 (1999-12-01), Bender et al.
patent: 6656932 (2003-12-01), Picard et al.
patent: 2002/0151555 (2002-10-01), Barvian et al.
patent: 2002/0151558 (2002-10-01), Andrianjara et al.
patent: 2002/0156061 (2002-10-01), Barvian et al.
patent: 2002/0156069 (2002-10-01), Picard et al.
patent: 2002/0161000 (2002-10-01), Barvian et al.
patent: 2002/0193377 (2002-12-01), Andrianjara et al.
patent: 2003/0004172 (2003-01-01), Harter et al.
patent: 2003/0078276 (2003-04-01), Andrianjara et al.
patent: 2003/0087924 (2003-05-01), Sorenson
patent: 2003/0130278 (2003-07-01), Gaudilliere et al.
patent: 2003/0144274 (2003-07-01), Bunker et al.
patent: 2003/0216402 (2003-11-01), Gaudilliere et al.
patent: 2003/0220355 (2003-11-01), Gaudilliere et al.
patent: 2003/0229103 (2003-12-01), Weithmann et al.
patent: 2004/0006077 (2004-01-01), Gaudilliere et al.
patent: 2082076 (1993-05-01), None
patent: 0935963 (1999-08-01), None
patent: 1138680 (2001-10-01), None
patent: WO 00/09485 (2000-02-01), None
patent: WO 00/44730 (2000-08-01), None
patent: WO 01/12611 (2001-02-01), None
patent: WO 01/63244 (2001-08-01), None
patent: WO 02/34726 (2002-05-01), None
patent: WO 02/34753 (2002-05-01), None
patent: WO 02/064080 (2002-08-01), None
patent: WO 02/064080 (2002-08-01), None
patent: WO 02/064547 (2002-08-01), None
patent: WO 02/064547 (2002-08-01), None
patent: WO 02/64568 (2002-08-01), None
patent: WO 02/064568 (2002-08-01), None
patent: WO 02/064571 (2002-08-01), None
patent: WO 02/064572 (2002-08-01), None
patent: WO 02/64578 (2002-08-01), None
patent: WO 02/064578 (2002-08-01), None
patent: WO 02/064595 (2002-08-01), None
patent: WO 02/064598 (2002-08-01), None
patent: WO 02/064599 (2002-08-01), None
patent: WO 03/032999 (2003-04-01), None
patent: WO 03/033478 (2003-04-01), None
patent: WO 03/076417 (2003-09-01), None
patent: WO 03/076417 (2003-09-01), None
patent: WO 04/000322 (2003-12-01), None
U.S. Appl. No. 10/071,032, filed Feb. 8, 2002, Dyer, et al.
U.S. Appl. No. 10/634,531, filed Aug. 5, 2003, Johnson.
U.S. Appl. No. 10/634,709, filed Aug. 5, 2003, Bunker, et al.
U.S. Appl. No. 10/634,162, Aug. 5, 2003, Wilson.
U.S. Appl. No. 10/634,473, filed Aug. 5, 2003, Bunker, et al.
U.S. Appl. No. 10/634,289, filed Aug. 5, 2003, Bunker, et al.
U.S. Appl. No. 10/634,180, filed Aug. 5, 2003, Bunker, et al.
U.S. Appl. No. 10/634,712, filed Aug. 5, 2003, Hicks, et al.
U.S. Appl. No. 10/634,181, filed Aug. 5, 2003, Li.
U.S. Appl. No. 10/634,489, filed Aug. 5, 2003, Roark.
U.S. Appl. No. 10/634,420, filed Aug. 5, 2003, Roark.
U.S. Appl. No. 10/634,716, filed Aug. 5, 2003, Nahra, et al.
U.S. Appl. No. 10/634,288, filed Aug. 5, 2003, O'Brien.
U.S. Appl. No. 10/634,717, filed Aug. 5, 2003, Nahra, et al.
U.S. Appl. No. 10/634,177, filed Aug. 5, 2003, Wilson.
U.S. Appl. No. 10/634,290, filed Aug. 5, 2003, Wilson.
U.S. Appl. No. 10/634,182, filed Aug. 5, 2003, Li.
U.S. Appl. No. 10/634,419, filed Aug. 5, 2003, Hicks, et al.
U.S. Appl. No. 10/634,225, filed Aug. 5, 2003, Picard, et al.
U.S. Appl. No. 10/634,718, filed Aug. 5, 2003, Ortwine
U.S. Appl. No. 10/739,261, filed Dec. 18, 2003, Bunker, et al.
Chen, et al., Structure-Based Design of a Novel, Potent, and Selective Inhibitor for MMP-13 Utilizing NMR Spectroscopy and Computer-Aided Molecular Design, J. Am. Chem. Soc., 2000, pp. 9648-9654, vol. 122.
Lovejoy, et al., Crystal structures of MMP-1 and —13 reveal the structural basis for selectivity of collagenase inhibitors, Nature Structural Biology, 1999, pp. 217-221, vol. 6(3).
Moy, et al., High-resolution Solution Structure of the Catalytic Fragment of Human Collagenase-3 (MMP-13) Complexed with Hydroxamic Acid Inhibitor, J. Mol. Biol., 2000, pp. 671-689, vol. 302.
Mitchell, et al., Cloning, Expression, and Type II Collagenolytic Activity of Matrix Metalloproteinase-13 from Human Osteoarthritic Cartilage, J. Clin. Invest., 1996, pp. 761-768, vol. 97(3).
Neuhold, et al, Postnatal expression in hyaline cartilage of constitutively active human collagenase-3 (MMP-13) incuces osteoarthritis in mice, J. Clin. Invest., 2001, pp. 35-44, vol. 107 (1).
Dahlberg,et al, Selective Enhancement of Collagenase-Mediated Cleavage of Resident Type II Collagen in Cultured Osteoarthritic Cartilage and Arrest with a Synthetic Inhibitor that Spares Collagenase 1 (Matrix Metalloproteinase 1), Arthritis & Rheumatism, 2000, pp. 673-682, vol., 43(3).
Billinghurst,et al., Comparison of the Degradation of Type II Collagen and Proteoglycan in Nasal and Articular Cartilages Induced by Interleukin-1 and the Selective Inhibition of Type II Collagen Cleavage by Collagenase, Arthritis & Rheumatism, 2000, pp. 664-672, vol. 43(3).
Billinghurst, et al, Enhanced Cleavage of Type II Collagen by Collagenases in Osteoarthritic Articular Cartilage, J. Clin. Invest., 1997, pp. 1534-1545, vol. 99(7).
Hirota, et al., Novel Synthesis of Pyrido[3,4-d]Pyrimidines, Pyrido[2,3-d]Pyrimidines, and Quinazolines Via Palladium-Catalyzed Oxidative Coupling, Heterocycles, 1994, pp. 563-570, vol. 37(1).
Wernicke, et al., Cloning of Collagenase 3 from the Synovial Membrane and Its Expression in Rheumatoid Arthritis and Osteoarthritis, J. Rheum, 1996, pp. 590-595, vol. 23(4).
Reboul, et al, The New Collagenase, Collagenase-3, Is Expressed and Synthesized by Human Chondrocytes but not by Synoviocytes, J. Clin. Invest., 1996, pp. 2011-2019, vol. 97(9).
Freemont, et al., In situ zymographic localisation of type II collagen degrading activity in osteoarthritic human articular cartilage, Am Rheum Dis, 1999, pp. 357-365, vol. 58.
Search Report from International Application No. PCT/IB03/03613.
Ashbrook Charles W.
Balasubramanian Venkataraman
Crissey Todd M.
Purchase, Jr. Claude F.
Warner-Lambert Company LLC
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