Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2006-06-06
2006-06-06
Chan, Christina (Department: 1644)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S007200, C435S007210, C530S350000, C530S387100, C530S388220
Reexamination Certificate
active
07056677
ABSTRACT:
This invention provides pharmaceutical compositions and methods for controlling and modifying Natural Killer (NK) cell and T cell functions by manipulation of “mast cell function-associated antigen,” or “MAFA,” polypeptide-mediated cell signaling. The invention provides a pharmaceutical compositions and methods using an agent that specifically binds to an MAFA ligand on a target cell and prevents or inhibits NK- or T cell-expressed cell surface MAFA from binding to the MAFA ligand on the target cell. Preventing or inhibiting an NK- or a T cell-expressed cell surface MAFA from binding to the MAFA ligand on the target cell prevents or inhibits the cell surface MAFA from generating an inhibitory signal to the NK or the T cell. The invention also provides pharmaceutical compositions and methods using an agent that specifically binds to an NK- or a T cell-expressed cell surface MAFA and prevents or inhibits the NK- or T cell-expressed cell surface MAFA from binding to a MAFA ligand or generating an inhibitory signal to the NK or the T cell. The invention also provides pharmaceutical compositions and methods using an agent that specifically binds to an NK- or a T cell-expressed cell surface MAFA and inhibits an NK cell or T cell activity.
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Mikayama Toshifumi
Takahasi Nobuaki
Chan Christina
Gemini Science, Inc.
Huynh Phuong N
Pillsbury Winthrop Shaw & Pittman LLP
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