Process for preparing isothiazolones

Details Process for preparing isothiazolones Process for preparing isothiazolones

1986-08-04

1989-09-19

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

564131, 564162, 564192, 564204, 564207, 564161, C07D27502, C07C10208, C07C14906, C07C14914

Patent

active

048683108

ABSTRACT:
The process involves the cofeeding of an acrylonitrile with an appropriate alcohol or its equivalent and a strong acid to form an acrylamide which is thiolated to form a mercapto-propionamide which is halogenated to afford the desired biocidally active isothiazolones. This invention relates to a novel process for preparing N-substituted 3-mercaptopropionamides, an intermediate in the preparation of isothiazolones.

REFERENCES:
patent: 3022344 (1962-02-01), Heininger et al.
patent: 3029279 (1962-04-01), Kondo
patent: 3151157 (1964-09-01), Fugate et al.
patent: 3840586 (1974-10-01), Chiba et al.
patent: 3849430 (1974-11-01), Lewis et al.
patent: 4052440 (1977-10-01), Gladstone et al.
patent: 4105431 (1978-08-01), Lewis et al.
Bauer et al., J. Org. Chem., 26, p. 1443 (1961).
Glikmans et al., Bull. Soc. Chim. France, p. 1376 (1966).
Krimen et al., Organic Reactions, 17, pp. 261 and 271, (1969).
"Handbook of Chemistry and Physics", (53rd Ed.), R. C. Weast (Editor), p. C-190 (1973).
Zh. Org. Khim., 5, 1938 (1969), "Kinetics of the Addition of Thiourea to Acrylic Acid".
Abstract for Japan Patent 59/98047 (6/6/84).

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