Reagents and methods useful for detecting diseases of the...

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Reexamination Certificate

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C536S001110, C536S018700, C536S022100, C536S023100, C435S069100, C435S085000, C435S091100, C435S091200, C530S300000, C530S350000

Reexamination Certificate

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07122653

ABSTRACT:
A set of contiguous and partially overlapping RNA sequences and polypeptides encoded thereby, designated as PS190 and transcribed from prostate tissue is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the prostate, such as prostate cancer. Also provided are antibodies which specifically bind to PS190-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific PS190 polypeptide, which molecules are useful for the therapeutic treatment of prostate diseases, tumors or metastases.

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Boehringer Mannheim Biochemicals 1991 Catalog, p. 557.
Tascilar et al. Role of tumor markers and mutations in cells and pancreatic juice in the diagnosis of pancreatic cancer. Annals of Oncology 10, Suppl. 4: S107-S110, 1999.

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