Synthesis of nitrogen heterocycles

Details Synthesis of nitrogen heterocycles Synthesis of nitrogen heterocycles

1988-05-27

1989-09-19

Hollrah, Glennon H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546139, 546149, 546153, 546157, 546166, 546181, 548486, 548508, C07D21724, C07D21522

Patent

active

048683043

ABSTRACT:
A method of synthesizing nitrogen heterocycles such as indoles, indolines, oxindoles, quinolines, isoquinolines, and isoquinolones, all of which are pharmacologically active. The method involves cyclizing a haloaryl alkene in the presence of a catalytically effective amount of a palladium(II) ion source and in the presence of a cyclizing promoting base such as an alkali metal salt.

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