Chemistry: electrical and wave energy – Apparatus – Electrophoretic or electro-osmotic apparatus
Reexamination Certificate
2006-12-26
2006-12-26
Noguerola, Alex (Department: 1753)
Chemistry: electrical and wave energy
Apparatus
Electrophoretic or electro-osmotic apparatus
C204S604000
Reexamination Certificate
active
07153407
ABSTRACT:
An electrophoresis apparatus is generally disclosed for sequentially analyzing a single sample or multiple samples having one or more analytes in high or low concentrations. The apparatus comprises a relatively large-bore transport capillary which intersects with a plurality of small-bore separation capillaries. Analyte concentrators, having antibody-specific (or related affinity) chemistries, are stationed at the respective intersections of the transport capillary and separation capillaries to bind one or more analytes of interest. The apparatus allows the performance of two or more dimensions for the optimal separation of analytes.
REFERENCES:
patent: 4816123 (1989-03-01), Ogan et al.
patent: 5045172 (1991-09-01), Guzman
patent: 5198091 (1993-03-01), Burolla et al.
patent: 5202010 (1993-04-01), Guzman
patent: 5246577 (1993-09-01), Fuchs et al.
patent: 5318680 (1994-06-01), Fishman et al.
patent: 5324401 (1994-06-01), Yeung et al.
patent: 5340452 (1994-08-01), Brenner et al.
patent: 5348633 (1994-09-01), Karger et al.
patent: 5413686 (1995-05-01), Klein et al.
patent: 5439578 (1995-08-01), Dovichi et al.
patent: 5453382 (1995-09-01), Novotny et al.
patent: 5498324 (1996-03-01), Yeung et al.
patent: 5516409 (1996-05-01), Kambara
patent: 5560811 (1996-10-01), Briggs et al.
patent: 5582705 (1996-12-01), Yeung et al.
patent: 5637458 (1997-06-01), Frankel et al.
patent: 5730850 (1998-03-01), Kambara et al.
patent: 5741639 (1998-04-01), Ensing et al.
patent: 5800692 (1998-09-01), Naylor et al.
patent: 5856174 (1999-01-01), Lipshutz et al.
patent: 5944971 (1999-08-01), Foote
patent: 5958202 (1999-09-01), Regnier et al.
patent: RE36350 (1999-10-01), Swedberg et al.
patent: 6001230 (1999-12-01), Burolla
patent: 6007690 (1999-12-01), Nelson et al.
patent: 6010607 (2000-01-01), Ramsey
patent: 6010608 (2000-01-01), Ramsey
patent: 6013165 (2000-01-01), Wiktorowicz et al.
patent: 6020208 (2000-02-01), Hutchens et al.
patent: 6150180 (2000-11-01), Parce et al.
patent: 6224728 (2001-05-01), Oborny et al.
patent: 6375901 (2002-04-01), Robotti et al.
patent: 6387234 (2002-05-01), Yeung et al.
patent: 6395169 (2002-05-01), Hindsgaul et al.
patent: 6406604 (2002-06-01), Guzman
patent: 6415821 (2002-07-01), Kamholz et al.
patent: 6534262 (2003-03-01), McKernan et al.
patent: 6544396 (2003-04-01), Cong et al.
patent: 6554986 (2003-04-01), Mathies et al.
patent: 6562214 (2003-05-01), Amrhein et al.
patent: 6596140 (2003-07-01), Nordman et al.
patent: 6613212 (2003-09-01), Siebert et al.
patent: 6616824 (2003-09-01), Tanaka
patent: 6627453 (2003-09-01), Hindsgaul et al.
patent: 6635164 (2003-10-01), Anazawa et al.
patent: 6875403 (2005-04-01), Liu et al.
patent: 2002/0054835 (2002-05-01), Robotti et al.
patent: 2002/0058273 (2002-05-01), Shipwash
patent: 2002/0115201 (2002-08-01), Barenburg et al.
patent: 2003/0027354 (2003-02-01), Geli
patent: 2003/0134415 (2003-07-01), Yamanashi et al.
patent: 0793098 (1997-09-01), None
patent: 1048950 (2000-11-01), None
patent: 1048951 (2000-11-01), None
patent: 0666980 (2002-05-01), None
patent: 1357378 (2003-10-01), None
patent: WO 95/10344 (1995-04-01), None
patent: WO 95/10344 (1995-04-01), None
patent: WO 97/11362 (1997-03-01), None
patent: WO 98/23950 (1998-06-01), None
patent: WO 00/30751 (2000-06-01), None
patent: WO 00/65354 (2000-11-01), None
patent: WO 02/44703 (2002-06-01), None
patent: WO 02/48716 (2002-06-01), None
patent: WO 02/059592 (2002-08-01), None
patent: WO 03/27028 (2003-04-01), None
patent: WO 03/038424 (2003-05-01), None
patent: WO 03/48755 (2003-06-01), None
patent: WO 03/059935 (2003-07-01), None
patent: WO 03/087772 (2003-10-01), None
“Affinity Chromatography,”Cuatrecasas and Anfinsen, Annual Review of Biochemistry 40, pp. 259-278. No month available (1971).
“Isotachophoresis Electrodesorption of Proteins from an Affinity Adsorbent on a Microscale,” Kasicka and Prusik, Journal of Chromatography 273(1), pp. 117-128 (Mar. 11, 1983).
“Desorption Isotachophoresis—Quantitative Characterization of Sorption and Desorption Conditions,” Kasicka and Prusik, Journal of Chromatography 273(1), pp. 75-80 (Feb. 22, 1985).
“The Use of a Concentration Step to Collect Urinary Components Separated by Capillary Electrophoresis and Further Characterization of Collected Analytes by Mass Spectrometry,” Guzman et al., Journal of Liquid Chromatography 14(5), pp. 997-1015 (Mar. 1991).
“Enzymophoresis of Nucleic Acids by Tandem Capillary Enzyme Reactor-Capillary Zone Electrophoresis,” Nashabeh and Ziad El Rassi, Journal of Chromatography 596(2), pp. 251-264 (Apr. 10, 1992).
“Switching Valve with Internal Micro Precolumn for On-Line Sample Enrichment in Capillary Zone Electrophoresis,” Debets et al., Journal of Chromatography 608(1-2), pp. 151-158 (Sep. 11, 1992).
“On-Line Peptide Mapping by Capillary Electrophoresis,” Amankwa and Kuhr, Analytical Chemistry 65(19), pp. 2693-2697 (Oct. 1, 1993).
“Preparation and Evaluation of an On-Line Preconcentrator for Capillary Electrophoresis,” Hoyt, Jr. et al., Journal of Microcolumn Separations 5(4), pp. 325-330, No month available (1993).
“On-Line Sample Preconcentration on a Packet-Inlet Capillary for Improving the Sensitivity of Capillary Electrophoresis of Pharmaceuticals,” Swartz and Merion, Journal of Chromatography 632(1-2), pp. 209-213 (Feb. 19, 1993).
“Immunoaffinity Capillary Electrophoresis Analysis of Cyclosporin in Tears,” Phillips and Chmielinska, Biomedical Chromatography 8(5), pp. 242-246 (Sep.-Oct. 1994).
“Optimization of On-Line Peptide Mapping by Capillary Zone Electrophoresis,” Licklider and Kuhr, Analytical Chemistry 66(24), pp. 4400-4407 (Dec. 15, 1994).
“The Use of Solid Phase Concentrators for On-Line Preconcentration of Metallothionein Prior to Isoform Separation by Capillary Zone Electrophoresis,” Beattie et al., Electrophoresis 16(3), pp. 322-328 (Mar. 1995).
“Selective Preconcentration for Capillary Zone Electrophoresis Using Protein G Immunoaffinity Capillary Chromatography,” Cole and Kennedy, Electrophoresis 16(4), pp. 549-556 (Apr. 1995).
“Sensitivity Enhancement and Second-Dimensional Information from Solid Phase Extraction-Capillary Electrophoresis of Entire High-Performance Liquid Chromatography Fractions,” Strausbauch et al., Electrophoresis 16(4), pp. 541-548 (Apr. 1995).
“Michaelis-Menten analysis of immobilized enzyme by affinity capillary electrophoresis,” Yoshimoto et al., Journal of Pharmaceutical and Biomedical Analysis 13(4-5), pp. 483-488 (Apr. 1995).
“Biomedical Applications of On-Line Preconcentration-Capillary Electrophoresis Using an Analyte Concentrator: Investigation of Design Options,” Guzman, Journal of Liquid Chromatography 18(18&19), pp. 3751-3768 (Jun. 1995).
“Capillary enzymophoresis of nucleic acid fragments using coupled capillary electrophoresis and capillary enzyme microreactors having surface-immobilized RNA-modifying enzymes,” Mechref and El Rassi, Electrophoresis 16(11), pp. 2164-2171 (Nov. 1995).
“Immobilization of Antibodies as a Versatile Tool In Hybridized Capillary Electrophoresis,” Ensing and Paulus, Journal of Pharmaceutical and Biomedical Analysis 14(3), pp. 305-316 (Jan. 1996).
“On-Capillary Sample Preconcentration Incorporated in Chiral Capillary Electrophoresis,” He et al., Analytical Sciences 12, pp. 177-181 (Apr. 1996).
“Preconcentration and Microreaction Technology On-Line with Capillary Electrophoresis,” Tomlinson et al., Journal of Chromatography A 744(1-2), pp. 3-15 (Sep. 13, 1996).
“Protein Identification by Solid Phase Microextraction-Capillary Zone Electrophoresis-Microelectrospray-Tandem Mass Spectrometry,” Figeys et al., Nature Biotechnology 14(11), pp. 1579-1583 (Nov. 1996).
“Consecutive protein digestion and peptide derivatization employing an on-line analyte concentrator to map proteins using capillary electrophoresis,” G
Jeffer Mangels Butler & Marmaro LLP
Noguerola Alex
Princeton Biochemicals, Inc.
LandOfFree
Multi-dimensional electrophoresis apparatus does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Multi-dimensional electrophoresis apparatus, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Multi-dimensional electrophoresis apparatus will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3695559