Process for production of optically active...

Chemistry: molecular biology and microbiology – Process of utilizing an enzyme or micro-organism to destroy... – Resolution of optical isomers or purification of organic...

Reexamination Certificate

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Reexamination Certificate

active

07148055

ABSTRACT:
The present invention provides a method for preparing optically active 3-hydroxypentanenitrile with high yield. Optically active 3-hydroxypentanenitrile is prepared by stereoselectively reducing 3-ketopentanenitrile by action of an enzyme, which asymmetrically reduces 3-ketopentanenitrile to optically active 3-hydroxypentanenitrile. Also, alkali metal salt of 3-ketopentanenitrile, which is a stable compound without problems regarding storage, can be efficiently obtained.

REFERENCES:
patent: WO 94/21617 (1994-09-01), None
patent: WO 2005/044973 (2005-05-01), None
Hackler, R.E., et al., “The Syntheses of 5-Amino-3-t-butylisothiazole and 3-Amino-5-t-butylisothiazole,”Journal of Heterocyclic Chemistry, vol. 26, No. 6, 1989, pp. 1575-1578.
Kiljunen, E., et al., “Novel (R)-Oxynitrilase Sources for the Synthesis of (R)-Cyanohydrins in Diisopropyl Ether,”Tetrahedron: Asymmetry, vol. 8, No. 8, Apr 24, 1997, pp. 1225-1234.
Effenberger, F., et al., “Enantioselektive Veresterung Racemisher Cyanhydrine und Enantioselektive Hydrolyse Oder Umesterung Racemisher Cyanhydrine und Enantioselektive Hydrolyse Oder Umesterung Racemischer Cyanhydrinester Mittels Lipasen,”Liebigs Annalen Der Chemie, No. 1, 1991, pp. 47-54.
Supplementary Partial European Search Report from Application No. EP 02 80 0753, Oct. 27, 2005, 6 pages.
Itoh, Toshiyuki et al., “Thiacrown Ether Technology in Lipase-Catalyzed Reaction: Scope and Limitation for Preparing Optically Active 3-Hydroxyalkanenitriles and Application to Insect Pheromone Synthesis,”J. Org. Chem., vol. 62, No. 26, 1997, pp. 9165-9172.
International Search Report From Corresponding International Application No. PCT/JP02/10312, Dated Jan. 28, 2003, 3 Pages.

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