Preparation of anti-T-lymphocyte globulin

Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

260112R, 424 85, 424 88, 435 68, 4351722, 435240, 435241, 436548, 436543, C07G 700, A61K 39395

Patent

active

045419531

ABSTRACT:
Anti-T-lymphocyte globulin is prepared from the serum of immunized animals. Cells of the cell line JM are used for immunization. Anti-T-lymphocyte globulin is prepared by means of hybrid cells, which are obtained by a hybridization of myeloma cells capable of antibody synthesis with B-lymphocytes from animals or human beings. Said lymphocytes have a specificity against an antigen which is introduced. Cells of the cell line JM or their products are used as an antigen.

REFERENCES:
patent: 4361549 (1982-11-01), Kung et al.
patent: 4361550 (1982-11-01), Kung et al.
patent: 4363799 (1982-12-01), Kung et al.
patent: 4364933 (1982-12-01), Kung et al.
Vol. 20: Immunological Diagnosis of Leukemias and Lymphomas, "Characterization of `T` and `Non-T` Cell Lines Established from Children with Acute Lymphoblastic Leukemia and Non-Hodgkin Lymphoma After Leukemic Transformation", 1977, pp. 265-269.
Thomas et al, "T Cell-Specific Activity in Rabbit Anti-Human Thymocyte Globulin", 1978, pp. 97-102.
Schneider, et al., "Characterization of EBV-Genome Negative `Null` and `T` Cell Lines Derived from Children with Acute Lymphoblastic Leukemia and Leukemic Transformed Non-Hodgkin Lymphoma", 1977, pp. 621-626.
Schwenk et al, "Difference in Distribution and Dynamics of Cell-Markers on T-Lymphoblasts Compared to T-Lymphocytes", 1976, pp. 215-219.
Rodt et al, "Characterization of Antigens on Leukemic Cells and Cell Lines Using Specific Heterologous Antisera", 1977, pp. 573-578.
Schwenk H. U. et al, "Detection of Lymphoblasts in Remission Bone Marrow Using Immunological Markers", 1977, pp. 700-704.
Schwenk et al, "Binding of Lectins to Leukemic Cell Lines", 1980, pp. 7-15.
Minowada et al, "Marker Profiles of Human Leukemia and Lymphoma Cell Lines", 1981, pp. 91-100.
Richard W. Smith et al, "The Immunosuppressive Potency of Anti-Lymphocyte Serum is Related to Activity Against Human Thymic Lymphocyte-Specific Antigens", 1974; pp. 503-507.
Gillis et al., "Biochemical and Biological Characterization of Lymphocyte Regulatory Molecules", 1980, pp. 1709-1719.
Lakow et al, "Human T Cell Hybridomas Specific for Epstein Barr Virus-Infected B Lymphocytes", 1983, pp. 169-172.
Mayer et al, "Human T Cell Hybridomas Secreting Factors for IgA-Specific help, Polyclonal B Cell Activation, and B Cell Proliferation", 1982, pp. 1860-1865.
DeFreitas et al, "Antigen-Specific Human T-Cell Hybridomas with Helper Activity (Mutant T-Cell Lines/Cell Fusion/Tetanus Toxoid/Interleukin 2)", 1982, pp. 6646-6650.
Cassel et al, "Phorbol Ester Modulation of T-Cell Antigens in the Jurkat Lymphoblastic Leukemia Cell Line", 1983, pp. 4582-4586.
Pawelec et al, "Constitutive Interleukin 2 Production by the Jurkat Human Leukemic T Cell Line", 1982, pp. 387-392.
Hans-Ulrich Schwenk et al, "Cell Cycle Dependency of a T-Cell Marker on Lymphoblasts", 1975, pp. 299-306.
Kenneth Sell, et al; "Evaluation of Human Cultured Lymphoblasts as a Source of Antigen for Production of Immunosuppressive Antilymphocyte Serum"; 1973; pp. 541-547
Borella et al., J. of Immunology, 118(1), (1977), 309-315.
Barrett et al., Lancet, May 1, 1976, 940-941.
Levy et al., Proc. Natl. Acad. Sci., USA, 76(12), 1979, 6552-6556.
Schneider et al., Int. J. Cancer, 19, 621, 662, 652 & 626 (1977).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Preparation of anti-T-lymphocyte globulin does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Preparation of anti-T-lymphocyte globulin, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Preparation of anti-T-lymphocyte globulin will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-369209

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.