Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2006-10-03
2006-10-03
Berch, Mark L. (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C540S302000, C540S200000
Reexamination Certificate
active
07115595
ABSTRACT:
Carbapenem compounds having a substituted phenyl or a substituted thienyl directly attached to the3-position of carbapenem nucleus as represented by the formula:wherein Ring E is benzene ring or thiophene ring; R1is optionally OH-substituted C1-3alkyl; R2and R3represent each H, optionally substituted lower alkyl, etc.; R is H, or a group which is hydrolyzed in the living body to regenerate a carboxyl group, etc.; X is O or S; and Y represents H, lower alkyl, etc., or pharmaceutically acceptable salts thereof and medicaments containing said compound as the active ingredient. These compounds exhibit an excellent antibacterial activity over a broad range of Gram-positive and Gram-negative bacteria, in particular, penicillin-resistantStreptococcus pneumoniae(PRSP) which has been isolated at an elevated frequency in recent years and thus causes a serious clinical problem, andHaemophilus influenzaewhich has acquired resistance against the existing β-lactam antibiotics over a wide scope due to penicillin-binding protein (PBP) mutations such as β-lactamase non-producing ampicillin-resistant (BLNAR)Haemophilus influenzae.
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Sasaki Akira
Sunagawa Makoto
Berch Mark L.
Dainippon Sumitomo Pharma Co. ,Ltd.
Wenderoth , Lind & Ponack, L.L.P.
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