Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1988-03-21
1989-09-19
Lee, Mary C.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
548321, A61K 31415, C07D23370
Patent
active
048681970
ABSTRACT:
A sulfur analog of enoximone, 1,3-dihydro-4-methyl-5-[4-(methylthio)benzoyl]-2H-imidazol-2-thione, is reported to reduce reperfusion injury, the injry which occurs when molecular oxygen is reintroduced into an ischemic tissue. The compound could be used to prevent much of the damage which occurs to the heart of a heart attack victim.
REFERENCES:
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patent: 4405635 (1983-09-01), Schnettler et al.
Chemical Abstracts, vol. 90, No. 64361j (1979), abstracting Japanese Patent Appln. No. 78 52, 422, published Oct. 22, 1976, T. Endo, et al., inventors.
Chemical Abstracts, vol. 87, No. 152201a (1977), abstracting Japanese Patent Appln. No. 77 46,074, published Oct. 11, 1975, M. Miyoshi, et al., inventors.
R. C. Smith, J. C. Reeves, R. C. Dage, and R. A. Schnettler, Biochemical Pharmacology 36(9), 1457 (1987).
J. M. McCord, New Engl. J. Med. 312, 159 (1985).
Chemical Abstracts, vol. 101, No. 211047 (1984), abstracting S. Maeda, et al., Chem Pharm. Bull., Tokyo 32(7), 2536 (1984).
Dage Richard C.
Grisar J. Martin
Palopoli Frank P.
Schnettler Richard A.
Lee Mary C.
Merrell Dow Pharmaceuticals Inc.
Northington Zinna
Sayles Michael J.
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