Human nuclear protein having WW domain and polynucleotide...

Details Human nuclear protein having WW domain and polynucleotide... Human nuclear protein having WW domain and polynucleotide...

2006-06-27

2006-06-27

Ketter, James (Department: 1636)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C435S320100, C435S325000

Reexamination Certificate

active

07067642

ABSTRACT:
An isolated and purified human nucleoprotein containing the amino acid sequence of SEQ ID NO:1; a polynucleotide encoding this protein; and an antibody against this protein. The above protein and antibody are useful in diagnosing and treating the pathogenic conditions of cancer, etc. The above polynucleotide is usable in acquiring the protein in a large amount. By screening a low-molecular weight compound binding to this protein, drugs of a novel type (antitumor agents, etc.) can be searched for.

REFERENCES:
Chen et al. Charicterization of the WW domain of human Yes-associated protein and its polyproline containing ligands JBC Vo.272 No. 27, 1997 pp. 17070-17077.
P. Morris et al., “Phospho-Carboxyl-Terminal Domain Binding and the Role of a Prolyl Isomerase in Pre-mRNA 3′-End Formation”, Journal of Biological Chemistry, vol. 274, No. 44, Oct. 1999, pp. 31583-31587.
EMBL/GenBank/DDBJ, Accession No. AL137437.

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