Cephalosporin derivatives

Details Cephalosporin derivatives Cephalosporin derivatives

1985-11-15

1989-09-19

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514203, 540222, 540224, 540225, C07D50156, A61K 31545

Patent

active

048681733

ABSTRACT:
According to the invention there is provided a antibacterial cephalosporin derivative of the formula: ##STR1## in which X is sulphur, oxygen, methylene or sulphinyl; R3 is hydrogen or methoxy; R1 and R2 are known in the cephalosporin art and R4 is an aminomethyl group in which the amino group carries one of various positively charged nitrogen-containing species set out in the specification and optionally a further substituent selected from hydrogen, lower alkyl, benzyl or heteroarylloweralkyl groups.

REFERENCES:
patent: 4252802 (1981-02-01), Denzel et al.
patent: 4278793 (1981-07-01), Durckheimer et al.
patent: 4678781 (1987-07-01), Jung
Journal of Medicinal Chemistry, 1974, vol. 17, No. 12, pp. 1312-1315, "Semisynthetic-Lactam Antibiotics. 6.sup.1 Sulfocephalosporins and Their Antipseudomonal Activities".

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