Novel substances KS-501 and KS-502 and process for their prepara

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

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435 74, 536 41, 536 182, C12P 1944, C07G 300, C07H 1500

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active

048681598

ABSTRACT:
Novel physiologically active substances KS-501 and KS-502 having inhibitory activity on serotonin release from platelets and/or platelet aggregation are produced by culturing a microorganism of the genus Sporothrix.

REFERENCES:
patent: 3781267 (1973-12-01), Jaques et al.
patent: 4112075 (1975-09-01), Baschang et al.
Chemical Abstracts, vol. 100, 1984, p. 417, Abstract No. 207601a, Takata, M., "Correlations Among Culture Times, Sugar Composition and Biological Activities of Aporothrix s. Antigens".
Chemical Abstracts, vol. 91, 1979, p. 3726, Abstract No. 3729g; Nakamura, Y., "Purification and Isolation of a Biologically Active Peptido-Rhamnogalactan from Sporothrix s".
Chem. Pharm. Bull., 28, 3157-3162 (1980), Ninomiya, Y. T. et al.
J. Antibiot., 37, 469-474 (1984), Umehara, K. et al.
Agric. Bio. Chem., 50, 2723-2727 (1986), Oka, S. et al.
J. Antibiot., 37, 1153-1160 (1984), Umehara, K. et al.

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