Removal of plasmin(ogen) from protein solutions

Details Removal of plasmin(ogen) from protein solutions Removal of plasmin(ogen) from protein solutions

2006-10-24

2006-10-24

Saucier, Sandra E. (Department: 1651)

Drug, bio-affecting and body treating compositions

Extract, body fluid, or cellular material of undetermined...

Blood

C435S217000

Reexamination Certificate

active

07125569

ABSTRACT:
A method for specifically removing or isolating plasmin(ogen) or plasmin in presence of fibrinogen from a mixture containing plasmin(ogen) or plasmin by contacting the mixture with a rigid amino acid wherein the amino group of the amino acid and the carboxylic group of the amino acid are about 6–8 Angstroms, preferably about 7 Angstroms apart and the rigid amino acid is covalently bound to the support via the amino group of the amino acid.

REFERENCES:
patent: 3943245 (1976-03-01), Silverstein
patent: 1727839 (1992-04-01), None
patent: 90/09238 (1990-08-01), None
patent: 94/00483 (1994-01-01), None
Masahiro Iwamoto, “Plasminogen-Plasmin System IX. Specific Binding of Tranexamic Acid to Plasmin” 1975, pp. 573-585, XP-001021276.
Leonard A. Moroz et al., “Fibrinolysis in Normal Plasma and Blood: Evidence for Significant Mechanisms Independent of the Plasminogen-Plasmin System”, Blood, vol. 48, No. 4 (Oct. 1976), pp. 531-545, XP-001029014.

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