DNA encoding mammalian phosphodiesterases

Details DNA encoding mammalian phosphodiesterases DNA encoding mammalian phosphodiesterases

2006-10-17

2006-10-17

Slobodyansky, Elizabeth (Department: 1652)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

C435S252300, C435S325000, C536S023200

Reexamination Certificate

active

07122363

ABSTRACT:
The present invention relates to novel purified and isolated nucleotide sequences encoding mammalian Ca2+/calmodulin stimulated phosphodiesterases (CaM-PDEs) and cyclic-GMP-stimulated phosphodiesterases (cGS-PDEs). Also provided are the corresponding recombinant expression products of said nucleotide sequences, immunological reagents specifically reactive therewith, and procedures for identifying compounds which modulate the enzymatic activity of such expression products.

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