Benzimidazolidinone derivatives as muscarinic agents

Details Benzimidazolidinone derivatives as muscarinic agents Benzimidazolidinone derivatives as muscarinic agents

2006-08-08

2006-08-08

Richter, Johann (Department: 1621)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S210210, C514S217090, C514S321000, C514S322000, C514S367000, C514S375000, C514S394000, C540S480000, C540S603000, C546S198000, C546S199000, C548S152000, C548S217000, C548S304700

Reexamination Certificate

active

07087593

ABSTRACT:
Benzimidazolidinone derivative compounds, which increase acetylcholine signaling or effect in the brain, and highly selective muscarinic agonists, particularly for the M1and/or M4receptor subtypes, pharmaceutical compositions comprising the same, as well as methods of treating psychosis using these compounds are disclosed.

REFERENCES:
patent: 4254127 (1981-03-01), Vandenberk et al.
patent: 4861889 (1989-08-01), Helsley et al.
patent: 5707798 (1998-01-01), Brann
patent: 5718912 (1998-02-01), Thomspon et al.
patent: 5726188 (1998-03-01), Takano et al.
patent: 5756508 (1998-05-01), Thompson et al.
patent: 5789425 (1998-08-01), Takano et al.
patent: 6586435 (2003-07-01), Cereda et al.
patent: 0 816 362 (1998-01-01), None
patent: WO 96/13262 (1996-05-01), None
patent: WO 97/16186 (1997-05-01), None
patent: WO 97/16187 (1997-05-01), None
patent: WO 97/16192 (1997-05-01), None
patent: WO 99/32481 (1999-07-01), None
patent: WO 01/83472 (2001-11-01), None
patent: WO 02/24662 (2002-03-01), None
patent: WO 03/028650 (2003-04-01), None
U.S. Appl. No. 10/408,192, filed Apr. 2003, Kelly et al.
Verma et al., Synthesis and Antibacterial Activity of Certain 3-Substituted Benzoxazolinones, Journal of Pharmaceutical Sciences, 1968, 57 (1), 39-44.
Bodick et al., Effects of xanomeline, a selective muscarinic receptor agonist, on cognitive function and behavioral symptoms in alzheimer disease, Arch. Neurol. 54:465 (1997).
Bonner et al, Cloning and expression of the human and rat m5 muscarinic acetylcholine receptor genes, Neuron 1:403 (1988).
Bonner et al., Identification of a family of muscarinic acetylcholine receptor genes, Science 237:527 (1987).
Braüner-Osborne, H.B. and Brann, M.R., Pharmacology of muscarinic acetylcholine receptor subtypes (m1-m5): high throughput assays in mammalian cells, Eur. J. Pharmacol. 295:93-102 (1996).
Bymaster et al., Potential role of muscarinic receptors in schizophrenia, Life Sci. 64:527 (1999).
Bymaster et al., Unexpected antipsychotic-like activity with the muscarinic receptor ligand (5R,6R)6-(3-propylthio-1,2,5-thiadiazol-4-yl)-1-azabicyclo[3.2.1]octane, Eur. J. Pharmacol. 356:109 (1998).
Cakir, et al., Synthesis and antinociceptive activity of some 3-substituted benzothiazolone derivatives, II Farmaco, 54:846 (1999).
Chahine, M. et al., Functional expression and properties of the human skeletal muscle sodium channel. Pfluegers Arch. 427:136-142 (1994).
Felder, et al., Therapeutic opportunities for muscarinic receptors in the central nervous system, J. Med. Chem. 43:4333 (2000).
Friedman, et al., Pharmacologic strategies for augmenting cognitive performance in schizophrenia, Biol. Psychiatry, 45:1 (1999).
Rowley, et al., Current and novel approaches to the drug treatment of schizophrenia, J. Med. Chem. 44:477 (2001).
Sauerberg, et al., Muscarinic agonists with antipsychotic-like activity: structure-activity relationships of 1,2,5-thiadiazole analogues with functional dopamine antagonist activity, J. Med Chem 41:4378 (1998).
Shannon et al., Xanomeline: a novel muscarinic receptor agonist with functional selectivity for M1receptors, J. Pharmacol. Exp. Ther. 269:271 (1994).
Shannon et al., Muscarinic receptor agonists, like dopamine receptor antagonist antipsychotics, inhibit conditioned avoidance response in rats, J. Pharmacol. Exp. Ther. 290:901 (1999).
Shannon et al., Xanomeline, a M1/M4preferring muscarinic cholinergic receptor agonist, produces antipsychotic-like activity in rats and mice, Schizophrenia Res. 42:249 (2000).
Stormann et al., Molecular cloning and expression of a dopamine D2 receptor from Human retina, Mol. Pharmacol. 37:1-6 (1990).
H. Itani, et al., “Novel Potent Antagonists of Human Neuropeptide Y Y5 Receptors,”Bioorganic & Medicinal Chemistry Letters, vol. 12 (2002) 799-802.
Supplementary European Search Report for Application No. EP 02 76 3824, Sep. 22, 2005.

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