Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Monoclonal antibody or fragment thereof
Reexamination Certificate
2006-11-21
2006-11-21
Gambel, Phillip (Department: 1644)
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Monoclonal antibody or fragment thereof
C424S130100, C424S133100, C424S141100, C424S158100, C530S387100, C530S387300, C530S388100, C530S388200, C530S388230
Reexamination Certificate
active
07138118
ABSTRACT:
Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.
REFERENCES:
patent: 4603106 (1986-07-01), Cerami et al.
patent: 4816567 (1989-03-01), Cabilly et al.
patent: 4822776 (1989-04-01), Cerami et al.
patent: 5075236 (1991-12-01), Yone et al.
patent: 5223395 (1993-06-01), Gero
patent: 5231024 (1993-07-01), Moeller et al.
patent: 5342613 (1994-08-01), Creaven et al.
patent: 5360716 (1994-11-01), Ohmoto et al.
patent: 5436154 (1995-07-01), Barbanti et al.
patent: 5654407 (1997-08-01), Boyle et al.
patent: 5658570 (1997-08-01), Newman et al.
patent: 5698195 (1997-12-01), Le et al.
patent: 5700788 (1997-12-01), Mongelli et al.
patent: 5730975 (1998-03-01), Hotamisligil et al.
patent: 5741488 (1998-04-01), Feldman et al.
patent: 5750105 (1998-05-01), Newman et al.
patent: 5776947 (1998-07-01), Kroemer et al.
patent: 5888511 (1999-03-01), Skurkovich et al.
patent: 5919452 (1999-07-01), Le et al.
patent: 5958413 (1999-09-01), Anagnostopulos et al.
patent: 5959087 (1999-09-01), Rathjen et al.
patent: 5993833 (1999-11-01), DeLarcharriere et al.
patent: 6015558 (2000-01-01), Hotamisligil et al.
patent: 6172202 (2001-01-01), Marcucci et al.
patent: 6190691 (2001-02-01), Mak
patent: 6194451 (2001-02-01), Alpegiani et al.
patent: 6309640 (2001-10-01), Cerami et al.
patent: 6419927 (2002-07-01), Cerami et al.
patent: 0212489 (1987-03-01), None
patent: 0218868 (1987-04-01), None
patent: 0260610 (1988-03-01), None
patent: 0350690 (1990-01-01), None
patent: 0351789 (1990-01-01), None
patent: 0351789 (1990-01-01), None
patent: 0380068 (1990-08-01), None
patent: 0393438 (1990-10-01), None
patent: 0453898 (1991-10-01), None
patent: 0486526 (1992-05-01), None
patent: 0512528 (1992-11-01), None
patent: 0526905 (1993-02-01), None
patent: 0288 088 (1994-03-01), None
patent: 0585705 (1994-03-01), None
patent: 0614984 (1994-09-01), None
patent: 0308378 (1994-11-01), None
patent: 0412486 (1994-11-01), None
patent: 0101681 (1994-12-01), None
patent: 0398327 (1995-03-01), None
patent: 0433900 (1995-09-01), None
patent: 0663836 (1997-07-01), None
patent: 61-047500 (1986-03-01), None
patent: 02-227095 (1990-09-01), None
patent: WO 89/08460 (1989-09-01), None
patent: WO 90/00902 (1990-02-01), None
patent: WO 90/01950 (1990-03-01), None
patent: WO 91/02078 (1991-02-01), None
patent: WO 91/04054 (1991-04-01), None
patent: WO 91/09967 (1991-07-01), None
patent: WO 92/01059 (1992-01-01), None
patent: WO 92/01472 (1992-02-01), None
patent: WO 92/07076 (1992-04-01), None
patent: WO 92/11383 (1992-07-01), None
patent: WO 92/13095 (1992-08-01), None
patent: WO 92/16553 (1992-10-01), None
patent: WO 93/02108 (1993-02-01), None
patent: WO 93/11236 (1993-06-01), None
patent: WO 94/08609 (1994-04-01), None
patent: WO 94/08619 (1994-04-01), None
The Merck Manual of Therapy and Diagnosis, Sixteenth Edition, 1992, edited by Berkow et al., published by Merck Research Laboratories, Rahway, NJ, see pp. 1305-1312.□□.
Geysen et al., Peptides, Proceedings of the Tenth American Peptide Symposium pp. 519-523, Marshall, ed. Escom, Leiden, 1988.
Beutler, B. et al., “Identity of tumour necrosis factor and the macrophage-secreted factor cachectin,”Nature, 316:552-554 (1985).
Beutler, B. et al., “Passive Immunization Against Cachectin/Tumor Necrosis Factor Protects Mice from Lethal Effect of Endotoxin,”Science, 229:869-871 (1985).
Morrison, Sherie L., “Transfectomas Provide Novel Chimeric Antibodies,”Science, 229:1202-1207 (1985).
Liang, Chi-Ming et al., “Production and Characterization of Monoclonal Antibodies Against Recombinant Human Tumor Necrosis Factor/Cachectin,”Biochem. &Biophy. Res. Comm., 137(2):847-854 (1986).
Hirai, Makoto et al., “Production and characterization of monoclonal antibodies to human tumor necrosis factor,”J. of Immun. Methods, 96:57-62 (1987).
Piguet, Pierre-Francois et al., “Tumor Necrosis Factor/Cachectin is an Effector of Skin and Gut Lesions of the Acute Phase of Graft-vs.-Host Disease,”J. Exp. Med., 166:1280-1289 (1987).
Meager, Anthony et al., “Preparation and Characterization of Monoclonal Antibodies Directed Against Antigenic Determinants of Recombinant Human Tumour Necrosis Factor (rTNF),”Hybridoma, 6(3):305-311 (1987).
Fendly, Brian M. et al., “Murine Monoclonal Antibodies Defining Neutralizing Epitopes on Tumor Necrosis Factor,”Hybridoma, 6(4):359-370 (1987).
Bringman, Timothy S. and Aggarwal, Bharat B., “Monoclonal Antibodies to Human Tumor Necrosis Factors Alpha and Beta: Applications for Affinity Purification, Immunoassays, and as Structural Probes,”Hybridoma, 6(5):489-507 (1987).
Tracey, Kevin J. et al., “Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia,”Nature, 330:662-664 (1987).
Nagai, M. et al., “Antibody to tumor necrosis factor (TNF) reduces endotoxin fever,”Experientia, 44:606-607 (1988).
Shimamoto, Yoshinori et al., “Monoclonal antibodies against human recombinant tumor necrosis factor: prevention of endotoxic shock,”Immunology Letters, 17:311-318 (1988).
Di Giovine, Francesco, S. et al., “Tumour necrosis factor in synovial exudates,”Annals of the Rheumatic Diseases, 47:768-772 (1988).
Collins, M.S. et al., “Immunoprophylaxis of Polymicrobic Cellulitis with a Human Monoclonal Antibody Against Lipopolysaccharide Antigen ofPseudomonas aeruginosa,” Abstract E-63,Abstracts of Annual Meeting 1989.
Exley, A.R. et al., “Monoclonal Antibody (Mab) to Recombinant Human Tumour Necrosis Factor (rhTNF) in the Prophylaxis and Treatment of Endotoxic Shock in Cynomolgus Monkeys,”Medical Research Society, Abstract 184, p. 50 (1989).
Cross, A.S. et al., “Pretreatment with Recombinant Murine Tumor Necrosis Factor α/Cachectin and Murine Interleukin 1 α Protects Mice from Lethal Bacterial Infection,”J. of Exp. Med., 169:2021-2027 (1989).
Engelmann, Hartmut et al., “A Tumor Necrosis Factor-binding Protein Purified to Homogeneity from Human Urine Protects Cells from Tumor Necrosis Factor Toxicity,”J. of Bio. Chem., 264(20):11974-11980 (1989).
Silva, Ayona T. et al., “Prophylactic and Therapeutic Effects of a Monoclonal Antibody to Tumor Necrosis Factor-α in Experimental Gram-Negative Shock,”J. of Infectious Diseases, 162:421-427 (1990).
Opal, Steven M. et al., “Efficacy of a Monoclonal Antibody Directed Against Tumor Necrosis Factor in Protecting Neutropenic Rats from Lethal Infection withPseudomonas aeruginosa,” J. of Infectious Diseases, 161:1148-1152 (1990).
Tavernier, Jan et al., “Analysis of the Structure-Function Relationship of Tumour Necrosis Factor. Human/Mouse Chimeric TNF Proteins: General Properties and Epitope Analysis,”J. Mol. Biol., 211:493-501 (1990).
Lucas, R. et al., “Generation and characterization of a neutralizing rat anti-rm TNF-α monoclonal antibody,”Immunology, 71:218-223 (1990).
Hinshaw, L.B. et al., “Survival of Primates in LD100Septic Shock Following Therapy with Antibody to Tumor Necrosis Factor (TNFα),”Circulatory Shock, 30:279-292 (1990).
Nophar, Yaron et al., “Soluble forms of tumor necrosis factor receptors (TNF-Rs). The cDNA for the type 1 TNF-R, cloned using amino acid sequence data of its soluble form, encodes both the cell surface and a soluble form of the receptor,”The EMBO Journal, 9(10):3269-3278 (1990).
Engelmann, Hartmut et al., “Two Tumor Necrosis Factor-binding Proteins Purified from Human Urine,”J. of Bio. Chem., 265(3):1531-1536 (
Daddona Peter
Ghrayeb John
Knight David
Le Junming
Siegel Scott
Centocor, Inc.
Gambel Phillip
Hamilton Brook Smith & Reynolds P.C.
New York University
LandOfFree
Methods of treating rheumatoid arthritis with anti-TNF... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods of treating rheumatoid arthritis with anti-TNF..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods of treating rheumatoid arthritis with anti-TNF... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3682712