Chemistry: molecular biology and microbiology – Apparatus – Including measuring or testing
Reexamination Certificate
2006-11-21
2006-11-21
Chin, Christopher L. (Department: 1641)
Chemistry: molecular biology and microbiology
Apparatus
Including measuring or testing
C422S050000, C422S051000, C422S068100, C422S082050, C422S082080, C422S186000, C422S186100, C435S287100, C435S287300, C436S514000, C436S518000, C436S526000
Reexamination Certificate
active
07138269
ABSTRACT:
A micro flow system is provided for separating particles, comprising a microfabricated member having a flow channel (5) defined therein for guiding a flow of a fluid containing the particles through the flow channel, first inlet means (2) positioned at one end of the flow channel for entering the fluid into the flow channel, first outlet means (7) positioned at the other end of the flow channel for discharging the fluid from the flow channel, the flow of the fluid containing the particles being controlled in such a way that one particle at the time passes a cross section of the flow channel, the member being positioned in a field that is substantially perpendicular to a longitudinal axis of the flow channel so that particles residing in the flow channel and being susceptible to the field across the flow channel are deflected in the direction of the field. Further, a micro flow system is provided for analyzing components of a fluid comprising a microfabricated member having a flow channel defined therein for guiding a flow of a fluid through the flow channel, first inlet means for entering particles into the flow channel, first outlet means for discharging of fluid from the flow channel and a plurality of assay sites located in the flow channel and comprising immobilized reagents whereby the fluid may be analyzed for a plurality of components while residing in the flow channel.
REFERENCES:
patent: 3560754 (1971-02-01), Kamentsky et al.
patent: 3827555 (1974-08-01), Kamentsky et al.
patent: 4279345 (1981-07-01), Allred
patent: 4738773 (1988-04-01), Muller-Ruchholtz et al.
patent: 4756427 (1988-07-01), Gohde et al.
patent: 4894146 (1990-01-01), Giddings
patent: 4910148 (1990-03-01), Sorensen et al.
patent: 5039426 (1991-08-01), Giddings
patent: 5053344 (1991-10-01), Zborowski et al.
patent: 5123901 (1992-06-01), Carew
patent: 5304487 (1994-04-01), Wilding et al.
patent: 5460797 (1995-10-01), Ryan
patent: 5465849 (1995-11-01), Wada et al.
patent: 5483469 (1996-01-01), Van den Engh et al.
patent: 5674743 (1997-10-01), Ulmer
patent: 5811099 (1998-09-01), Ryan
patent: 38 27 252 (1990-02-01), None
patent: 0 196 205 (1986-10-01), None
patent: 0 454 286 (1991-10-01), None
patent: 0 736 765 (1996-10-01), None
patent: WO 91/15750 (1991-10-01), None
patent: WO 93/22058 (1993-11-01), None
patent: WO 94/15193 (1994-07-01), None
patent: WO 96/09409 (1996-03-01), None
Blankenstein, Gert, “Microfabricated Flow System for Magnetic Cell and Particle Separation,”Scientific and Clinical Applications of Magnetic Carriersedited by Häfeli, et al., Plenum Press, New York, 1997.
Nakamura, Noriyuki, et al., “Detection and Removal ofEscherichia coliUsing Fluorescein Isothiocyanate Conjugated Monoclonal Antibody Immobilized on Bacterial Magnetic Particles,”Anal Chem.1993, 65, 2036-2039.
Tondra, Mark, et al., “Design of Integrated Microfluidic Device for Sorting Magnetic Beads in Biological Assays.”
Zborowski, Maciej, et al., “Continuous-Flow Magnetic Cell Sorting Using Soluble Imunomagnetic Label,”Scientific and Clinical Applications of Magnetic Carriersedited by Häfeli, et al., Plenum Press, New York, 1997.
Ahn, C.H. et al., “A Fully Integrated Micromachined Magnetic Particle Manipulator and Separator”, Proceeding of the workshop on Micro Electro Mechanical systems (MEM. OISO) Jan. 25-28, 1994, No. Workshop 7, Jan. 25, 1994, Institute of Electrical and Electronics Engineers, pp. 91-96.
Melamed et al., Flow Cytometry and Sorting, (Ed. Melamed et. Al., Wiley & Sons Inc., 1990, pp. 1-9 and 11-25.
Lea et al. (1990). Microspheres as immunoreagents for call identification and cell fractination. In Flow Cytometry and Sorting (eds. Melamed et al.) New York: Wiley-Liss. pp. 367-380.
Lett et al. (1990). Ultrasensitive molecular-level flow cytometry. In Flow Cytometry and Sorting (eds. Melamed et al.). New york: Wiley-Liss. pp. 381-396.
Kachel et al. (1990). Hydrodynamic properties of flow cytometry instruments. In Flow Cytometry and Sorting (eds. Melamed et al.). New York: Wiley-Liss. pp. 27-44.
Blankenstein et al. (1998). Modular concept of a laboratory on a chip for chemical and biochemical analysis. Biosen. Bioelectro. 13(3-4): 427-438.
Sun et al. (1998). Continuous, flow-through immunomagnetic cell sorting in a quadrupole filed. Cytometry. 33:469-475.
Hodder et al. (1997), Microfabricated flow chamber for fluorescence-based chemistries and stopped flow injection cytometry. Analyst. 122-883-887.
Moore et al. (1998). Lymphocyte fractionation using immunomagnetic colloid and a dipole magnet flow cell sorter. J. Biochem. Biophys. Methods. 37:11-33.
Hartig et al. (1992). Preparative continuous separation of biological particles by means of free-flow magnetophoresis in a free-flow electrophresis chamber. Electrophoresis. 13:674-676.
Zborowski et al. (1996). Magnetic flow sorting using a model system of human lymphocytes and a colloidal magnetic label. ASAIO J. 42(5):M666-671.
Chin Christopher L.
Foley & Hoag LLP
Inverness Medical Switzerland GmbH
Kamholz Scott E.
LandOfFree
Microflow system for particle separation and analysis does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Microflow system for particle separation and analysis, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Microflow system for particle separation and analysis will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3680981