Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1982-06-09
1985-04-23
Waltz, Thomas A.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
2604025, 549292, 562426, 562427, 514459, 514477, 514478, 514484, 514547, 514549, 514558, 514560, C07C14920, A61K 31335, A61K 3123
Patent
active
045130051
ABSTRACT:
There are described pharmacologically active compounds, useful in the treatment of allergic/inflammatory disorders involving SRS-A as causal mediator and which, in free acid form, are of formula I, ##STR1## in which R.sub.1 is (i) an aliphatic, saturated or unsaturated hydrocarbyl radical of up to 20 carbon atoms, unsubstituted or substituted by at least one substituent selected from halogen, hydroxy, C.sub.3-6 alkoxy, C.sub.3-6 cycloalkyl, aryl or heteroaryl, the cycloalkyl, aryl or heteroaryl being unsubstituted or substituted by at least one substituent selected from hydroxy, halogen and alkyl, alkenyl or alkynyl of up to 10 carbon atoms,
REFERENCES:
patent: 4311645 (1982-01-01), Rosenberger
patent: 4352757 (1982-10-01), Gleason et al.
Tetrahedron Letters, 22 (49) 4933; (26), 2505; (1981).
Tetrahedron Letters, 23 (10), 1023; (2), 167; (1982).
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J. Am. Chem. Soc., 102 (4), 1436; 5425; (1980).
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Prostaglandins, 19 (5), 645 (1980).
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Proc. Natl. Acad. Sci. USA, 78 (7), 4579; (5), 3195; (1981).
The International Symposium on Leukotrienes and Other Lipoxygenase Products, held in Florence, Italy on Jun. 10-12, 1981, Abstract, p. 22.
Ibid, p. 37.
Ibid, p. 77.
Advances in Prostaglandin, Thromboxane, and Leukotriene Research, vol. 9, Leukotrienes and Other Lipoxygenase Products (Raven Press, New York), pp. 223-227 (1982).
Baker Stephen R.
Jamieson William B.
Ross William J.
Todd Alec
Ashbrook Charles W.
Lilly Industries Limited
Waltz Thomas A.
Whale Arthur R.
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