Quinuclidine derivatives and medicinal compositions...

Details Quinuclidine derivatives and medicinal compositions... Quinuclidine derivatives and medicinal compositions...

2006-10-17

2006-10-17

Desai, Rita (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C546S133000

Reexamination Certificate

active

07122558

ABSTRACT:
A compound of formula (I), wherein B is a phenyl ring, a 5 to 10 membered heteroaromatic group containing one or more heteroatoms, or a naphthalenyl, 5,6,7,8-tetrahydronaphthalenyl, benzo[1,3]dioxolyl, or biphenyl group; R1, R2and R3each independently represent a hydrogen or halogen atom, or a hydroxy group, a phenyl group, —OR7, —SR7, —NR7R8, —NHCOR7, —CONR7R8, —CN, —NO2, —COOR7or CF3group, or a strait or branched, substituted or unsubstituted lower alkyl group, wherein R7and R8each independently represent a hydrogen atom, a straight or branched lower alkyl group, or together form an alicyclic ring; or R1and R2together form an aromatic or alicyclic ring or a heterocyclic group. n is an integer from 0 to 4; A represents a group selected from —CH2—, —CH═CR9—, —CR9═CH—, —CR9R10—, —CO—, —O—, —S—, —S(O)—, —S(O)2— and NR9, wherein R9and R10each independently represent a hydrogen atom, a straight or branched lower alkyl group, or together form an alicyclic ring; m is an integer from 0 to 8, provided that when m=0, A is not —CH2—; p is an integer from 1 to 2 and the substitution in the azonia bicyclic ring may be in the 2, 3 or 4 position including all possible configurations of the asymmetric carbons; R4represents a group of structure: (Formulae II) wherein R11represents a hydrogen or halogen atom, a hydroxy group, an alkoxy group, a nitro group, a cyano group, —CO2R12or —NR12R13, wherein R12and R13are identical or different and are selected from hydrogen and straight or branched lower alkyl groups, or a straight or branched, substituted or unsubstituted lower alkyl group; R5represents an alkyl group of 1 to 7 carbon atoms, an alkenyl group containing 2 to 7 carbon atoms, or a group of formula (III) wherein q=1 or 2 and R11iss a defined above; R6represents a hydrogen atom, a hydroxy group, a methyl group or a —CH2OH group; and X−represents a pharmaceutically acceptable anion of a mono or polyvalent acid.

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